目录号 | 产品详情 | 靶点 | |
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T76279 | Glucagon Receptor | ||
Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。 | |||
T76279L1 | Glucagon Receptor | ||
Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。 | |||
T78097L | Glucagon Receptor | ||
Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂,是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌 ,可用于研究肥胖和 2 型糖尿病 (T2D) 。 | |||
T76279L | |||
Retatrutide (LY3437943) TFA 是一种针对胰高血糖素受体(GCGR)、葡萄糖依赖性促胰岛素多肽受体(GIPR)和胰高血糖素样肽-1受体(GLP-1R)的三重激动剂肽。该化合物能有效抑制人GCGR、GIPR和GLP-1R,具有EC50值分别为5.79、0.0643和0.775 nM。主要用于肥胖研究领域。 | |||
T80079 | |||
Mazdutide (IBI-362; LY-3305677) TFA 是一款GLP-1R与GCGR的共激动剂,同时是长效合成胃泌酸调节素类似物。该化合物安全性和耐受性良好,适用于肥胖与T2D研究。 | |||
T76668 | |||
FC382K10W15 TFA 是一种胰高血糖素类似物和GLP-1R/GCGR 激动剂。FC382K10W15 TFA 可用于 2 型糖尿病的研究。 | |||
T76876 | |||
Volagidemab,一种针对胰高血糖素受体(GCGR)的拮抗性单克隆抗体(mAb),主要应用于1型糖尿病(T1D)的研究。 | |||
T80084 | |||
Retatrutide (LY3437943) acetate 是一种针对胰高血糖素受体(GCGR)、葡萄糖依赖性促胰岛素多肽受体(GIPR)和胰高血糖素样肽-1 受体(GLP-1R)的三重肽激动剂。该化合物能有效抑制这三种受体,其EC50值分别为GCGR 5.79 nM、GIPR 0.0643 nM和GLP-1R 0.775 nM,是肥胖研究领域的潜在工具。 | |||
T78658 | |||
Pemvidutide (TFA) 是一款针对GLP-1R/GCGR的双重激动剂,有助于显著降低体重、肝脏脂肪以及血清脂质水平。该化合物主要适用于非酒精性脂肪性肝炎(NASH)和肥胖症的研究领域。 | |||
T74421 | |||
Pemvidutide 是一种GLP-1R/GCGR 双重激动剂,可导致体重、肝脏脂肪和血清脂质的显著降低。Pemvidutide 可用于非酒精性脂肪性肝炎 (NASH) 和肥胖症的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02675 | GCGR Protein, Mouse, Recombinant (GST) | Mouse | E. coli | ||
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
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TMPH-01383 | GCGR Protein, Human, Recombinant (His & Myc) | Human | HEK293 | ||
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
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TMPH-01382 | GCGR Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli | ||
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
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