目录号 | 产品详情 | 靶点 | |
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T36370 | |||
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis. | |||
T78450 | |||
4-Di-1-ASP是一种苯乙烯基染料,适用于标记活脑组织中的神经胶质瘤细胞,常用于分析细胞的结构、活性、增殖以及内吞作用、胞吐和吞噬作用。同时,该染料也被用于观察活细胞的线粒体结构。在显微镜观察下,4-Di-1-ASP能够发射绿色荧光(λex/λem= 475/606 nm)。 | |||
TD0001 | Others | ||
SYBR GREEN 1 是一种不对称花青染料,用于检测核酸。它由一个 N-烷基化的苯并噻唑或苯并恶唑环系统组成,通过一甲基桥连接到吡啶鎓或喹啉鎓环系统。 SYBR Green I 与 dsDNA 的小沟结合,在 480 nm 波长处被激发。它具有 520 nm 的峰值荧光发射。 | |||
T79290 | DNA/RNA Synthesis | ||
SRE-II是一种可激活的光敏剂,具有降低的荧光和光敏能力,适用于光动力癌症研究。经羧酸酯酶催化的酰胺键断裂,SRE-II能转化为活性光敏剂SDU Red。在光照射下,SRE-II能诱发DNA损伤和促进细胞凋亡,是治疗三阴性乳腺癌的有希望的诊断试剂。 | |||
T82497 | |||
eGFP circRNA,能够编码由Aequorea victoria水母分离得到的绿色荧光蛋白。作为哺乳动物细胞培养中的常规直接检测报告蛋白,其在509 nm波长下发出鲜明的绿光。eGFP circRNA作为环状RNA转染的首选阳性对照,对于监测及提升转染效率具有重要意义。 | |||
T83931 | |||
JQ1-FITC是一种荧光BET溴结构域探针。它与BRD4(BD1)和BRD4(BD2)具有高亲和力绑定(KD,app值分别为6.5 nM和5.8 nM,使用GST标签的BRD4蛋白,通过CoraFluorTR-FRET实验测定;在荧光偏振实验中,对于BRD4(BD1)的值为58.7 nM)。激发和发射峰(λ)分别为495 nm和525 nm。 | |||
T75378 | |||
DCDAPH(Compound 2c)是用于β-淀粉样蛋白(Aβ)斑块检测的新型智能近红外探针,在PBS中λex/λem为597/665 nm。此化合物对Aβ具有高亲和性(Ki=37 nM,Kd=27 nM),并显示良好的血脑屏障渗透性,能够满足大多数体外及体内Aβ检测需求。 | |||
T82729 | |||
Chol-N3是一种chol基探针,具备生物正交反应特性。它配合SRM技术能够在静息活细胞表面实现纳米级脂质异质性的直接可视化。Chol-N3作为点击化学试剂,其Azide基团可参与铜催化的叠氮-炔环加成反应(CuAAc),并且能与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T80846 | |||
WAAG-3R 是一具有生物活性的肽,归属于ADAMTS家族(解整合素和金属蛋白酶带有血小板反应蛋白基序)。该肽用于裂解软骨主要结构成分聚集蛋白聚糖。特别地,Aggrecanase-1 (ADAMTS-4) 为人骨关节炎软骨中主要的肽类酶。WAAG-3R作为FRET肽,特定用于ADAMTS-4 (Aggrecanase-1) 的活性测定,其荧光光谱实验条件为Ex/Em = 340/420 nm。 | |||
TD0055 | |||
Fluo-8,AM is one of the most commonly used fluorescent probes to detect intracellular calcium concentration.Fluo-8, which penetrates the cell membrane and enters the cell, is cut by the intracellular esterase to form fluO-8, and thus is trapped in the cel |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04510 | PSAP/Prosaposin Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Prosaposin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.9 kDa and the accession number is A0A024QZQ2.
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TMPY-04336 | Orange fluorescent protein Protein, Discosoma sp, Recombinant (His) | Discosoma sp | E. coli | ||
OFPSparkTM is a red (orange) fluorescent protein (excitation/emission maxima are 549 and 566 nm, respectively) derived from DsRed. Possessing high photostability and pH stability, OFPSparkTM is more than twice brighter than mOrange2. Fast OFPSparkTM maturation makes it detectable in mammalian cells as early as within 8 hrs after transfection. OFPSparkTM can be expressed and detected in a wide range of organisms. Mammalian cells transiently transfected with OFPSparkTM expression vectors produce bright fluorescence in 8 hrs after transfection. No cytotoxic effects or visible protein aggregation are observed. For its monomer structure, OFPSparkTM performs well in some fusions and protein labeling applications.
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TMPY-00209 | PSAP/Prosaposin Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Prosaposin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61 kDa and the accession number is A6K3X0.
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TMPY-04268 | NUDC Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic region spans about 8 kb. NUDC was mapped to 1p34-p35 by fluorescence in situ hybridization. This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. Nuclear migration is essential for the growth, development, and cellular function of eukaryotes. NUDC protein plays an important role in nuclear migration. It is widely expressed in the testis, adrenal, and other tissues. NUDC protein is expressed highly in CNE-2 and HNE-2 cells. Anti-NUDC antibody could inhibit the growth of CNE-2 and HNE-2 cells.
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