目录号 | 产品详情 | 靶点 | |
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T10889 | GPR | ||
CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂,对 CRTH2 的 IC50 值为 ≤10 nM。CRTh2 antagonist 2 可用于雄激素性脱发的研究。 | |||
T2556 | Others HIV Protease | ||
Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素,通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。 | |||
T30161 | P450 | ||
EN3356 是一种可口服且具有选择性的类固醇 17-α- 羟化酶/C17,20 裂解酶(CYP17A1 或 CYP17)抑制剂,是一种非甾体类裂解酶选择性化合物,具有潜在的抗雄激素和抗肿瘤活性。 | |||
T1284 | Glucocorticoid Receptor Estrogen/progestogen Receptor Progesterone Receptor HIV Protease Autophagy | ||
Megestrol acetate (BDH1298) 是具有口服活性的合成孕激素。它还具有抗雄激素特性,可用于治疗厌食症和恶病质。 | |||
T2195L | |||
Epiandrosterone sulfate is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase of the adrenal hormone DHEA. | |||
T25961 | |||
Piperophos is an organophosphate with anti-androgenic activities. | |||
T20976 | |||
Clostebol acetate is a synthetic anabolic-androgenic steroid (AAS) and a derivative of testosterone. It acts as a prodrug of clostebol in the body. | |||
T25304 | |||
Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat luteal insufficiency. | |||
T19195 | Others | ||
Androstenediol 17-acetate is a synthetic anabolic-androgenic steroid and an androgen ester. | |||
T19716 | |||
1,3,5-Trihydroxyxanthone is a highly cytotoxic natural compound. It against a range of bacteria and yeasts.Anti-androgenic. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02672 | Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.
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TMPY-02155 | Prostatic Acid Phosphatase Protein, Human, Recombinant (His) | Human | HEK293 | ||
Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.
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