T36331
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Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2] |
T11310
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Others
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FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. |
T40602
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Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective potential in a rat model of spinal cord trauma. |
T39344
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Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2. |
T38469
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Beta Amyloid
Cysteine Protease
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(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) 是一种 cathepsin L 抑制剂,抑制 β-淀粉样蛋白诱导凋亡变化的倾向 。(Rac)-Z-Phe-Phe-FMK 通过 siRNA 敲低 LC3B 表达可抑制 PI 诱导的 IkappaBalpha 降解。 |
TP2101
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Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. |
T23555
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Others
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When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluorometh |
T10548
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Caspase
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Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates. |
TP2161
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Caspase
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Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM). |
TP2037
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Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro. |