T76665
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Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。 |
T73093
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Z-VRPR-FMK 是一种不可逆地 MALT1蛋白抑制剂。Z-VRPR-FMK 可通过抑制 MALT1诱导的 NF-κB 活化和 MMP 表达来抑制弥漫性大 B 细胞淋巴瘤的生长和侵袭。 |
T75938
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Z-VRPR-FMK (TFA) (VRPR) 为一种四肽类选择性及不可逆的粘膜相关淋巴组织淋巴瘤易位蛋白1 (MALT1) 抑制剂,具有抵抗甲型流感病毒 (IAV) 感染的能力。 |
T72435
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Z-LE(OMe)TD(OMe)-FMK 是一种选择性的 caspase-8抑制剂,可以抑制细胞凋亡。 |
T83963
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Z-DEVD-FMK Caspase-3 Inhibitor 是一种可渗透细胞膜的、不可逆的 caspase-3/CPP32 抑制剂,能够抑制肿瘤细胞的凋亡。在动物体内,它在大鼠发作后的海马区具有神经保护作用,且显著减少创伤后的细胞凋亡,并在诱发的大鼠创伤性脑损伤之前和之后改善神经学恢复情况。 |
T10845
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Others
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CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK. |
T69200
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CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and Bcl-x(L). CGP74514A treatment (5 microM; 18 hr) resulted in increased p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2). It also induced early (i.e., within 2 hr) inhibition of CDK1 activity and dephosphorylation of pRb, followed by pRb degradation, but did not block pRb phosphorylation at CDK2- and CDK4- specific sites. These findings indicate that the selective CDK1 inhibitor, CGP74514A , induces complex changes in cell cycle...... |