目录号 | 产品详情 | 靶点 | |
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T1924 | Apoptosis DUB | ||
LDN-57444 是一种可逆的,竞争性的,定向位点的泛素 C 末端水解酶 L1 抑制剂,IC50和Ki 值分别为 0.88 μM 和 0.40 μM。它还可抑制 UCH-L3 的活性,IC50值为 25 μM。 | |||
T4634 | DUB | ||
GNE-6776 是一种具有口服活性的选择性USP7抑制剂。 | |||
T4067 | DUB | ||
VLX1570 是蛋白酶体 DUB 活性的竞争性抑制剂,IC50 范围为 4.2 uM 至 8.6 uM。它对 USP14 有抑制作用。 | |||
T15464 | DUB | ||
HBX 19818 是一种特异性泛素特异性蛋白酶 7 (USP7) 抑制剂,IC50值为 28.1 μM。 | |||
T3555 | DUB | ||
ML364 是一种泛素蛋白特异性肽酶 (USP2) 抑制剂,具有抗增殖活性,IC50为1.1 μM,Kd=5.2 μM。它可直接结合 USP2,诱导细胞周期蛋白 D1 降解增加并导致细胞周期停滞。它增加线粒体活性氧水平,降低胞内 ATP 含量,可用于乳腺癌的研究。 | |||
T9375 | DUB | ||
IU1-248 是 IU1 的衍生物,是一种选择性 USP14 抑制剂,IC50 为 0.83 μM。 | |||
T12024 | DUB | ||
MF-094 是一种选择性 USP30抑制剂,IC50为120 nM。它增加蛋白质泛素化,加快有丝分裂。 | |||
T14852 | DUB | ||
C527 是一种泛 DUB 酶抑制剂,对 USP1/UAF1 复合物具有高效力,IC50值为0.88 μM。 | |||
T15729 | DUB | ||
LDN-91946 是一种有效且特异性的泛素 C-末端水解酶-L1 (UCH-L1) 抑制剂(Ki = 2.8 μM)。 | |||
T8464 | Apoptosis DUB | ||
RA-9 是一种高选择性蛋白酶体相关的 DUBs 抑制剂,具有良好的毒性和抗癌活性。它阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。它诱导卵巢癌细胞内质网应激反应,选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03011 | USP46 Protein, Human, Mouse, Recombinant | Human,Mouse | Baculovirus-Insect Cells | ||
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
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TMPY-02522 | OTUB2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
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TMPY-02974 | USP46 Protein, Human, Mouse, Recombinant (SUMO) | Human,Mouse | Baculovirus-Insect Cells | ||
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
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