目录号 | 产品详情 | 靶点 | |
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T11110 | DUB | ||
DUB-IN-1 是一种泛素特异性蛋白酶 (USP) 的活性抑制剂,对 USP8 的IC50值为 0.24 μM。 | |||
T9122 | DUB | ||
XL177A 是一种选择性不可逆的 USP7 抑制剂,IC50为 0.34 nM。它通过 p53 依赖性机制引发癌杀伤细胞作用。 | |||
T36682 | DUB | ||
USP30 inhibitor 18 是有效的USP30选择性抑制剂,IC50为 0.02 μM。它增加蛋白质泛素化并加速线粒体自噬。 | |||
T11209 | DUB | ||
EOAI3402143 是一种去泛素化酶抑制剂,以剂量依赖性抑制 Usp9x/Usp24和 Usp5,增加肿瘤细胞凋亡。 | |||
T15604 | DUB | ||
IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。 | |||
T1757 | DUB | ||
ML323 是一种有效的可逆的USP1-UAF1抑制剂,在Ub-Rho 测定实验中,IC50为 76 nM。在使用 K63 连接的双泛素 (di-Ub) 和单泛素化 PCNA 的正交凝胶测定中(Ub-PCNA)分别作为底物。 | |||
T11111 | DUB | ||
DUB-IN-2 是一种有效的去泛素酶抑制剂,能够抑制 USP8 的活性,IC50值为 0.28 μM。 | |||
T11112 | DUB | ||
DUB-IN-3 是强效去泛素酶 (USP) 酶抑制剂,对 USP8 的 IC50值为 0.56 μM。 | |||
T5461 | DUB | ||
GNE 6640 是一种选择性泛素特异性肽酶 7(USP7)的非共价抑制剂,其对全长USP7、USP7 催化结构域、全长USP43 以及 Ub-MDM2 的IC50值分别为 0.75 μM、0.43 μM、20.3 μM 和 0.23 μM。 | |||
T13268 | DUB | ||
USP7-IN-1 是泛素蛋白特异性蛋白酶的选择性、可逆性抑制剂,IC50为 77 μM,可用于癌症研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03011 | USP46 Protein, Human, Mouse, Recombinant | Human,Mouse | Baculovirus-Insect Cells | ||
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
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TMPY-02522 | OTUB2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
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TMPY-02974 | USP46 Protein, Human, Mouse, Recombinant (SUMO) | Human,Mouse | Baculovirus-Insect Cells | ||
USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.
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