TN3790
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Antifection
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Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫,IC50为26-27 μM. |
T15276
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Others
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Ferroquine (Ferrochloroquine) 是 Chloroquine 的二茂铁基类似物,具有抗疟疾活性。Ferroquine 具有杀疟原虫作用,机制是通过诱导氧化应激和随后的膜破坏。 |
T0392
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HCV Protease
Ferroptosis
Akt
Parasite
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Artemisinin (Qinghaosu) 是一种倍半萜烯内酯,是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。 |
T3266
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Others
Parasite
Autophagy
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Lumefantrine (dl-Benflumelol) 是一种抗疟药,用于治疗急性单纯性疟疾。与Artemether 联用,可提高疗效。 |
TN1905
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Antifection
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Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中,对谷氨酸诱导的毒性有显著的神经保护作用。 它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性,对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。 |
T3437
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lysosomal autophagy
Autophagy
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Lys05 是一种有效的水溶性溶酶体自噬抑制剂,具有抗肿瘤活性。在 MTT 试验中,对1205Lu、c8161、LN229 和 HT-29细胞系的IC50值分别为3.6、3.8、6 和7.9 μM。 |
T71619
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ST72 is a potent inhibitor of FP2. ST72 exhibited strong growth inhibition of chloroquine-sensitive (3D7; EC50 = 2.8 µM) and chloroquine-resistant (RKL-9; EC50 = 6.7 µM) strains of Plasmodium falciparum |
TN4202
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Antifection
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(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities. |
T20910
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Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT). |
T11006
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Others
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Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial. |