目录号 | 产品详情 | 靶点 | |
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T3693 | Others | ||
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) 是一种活性生化剂。 | |||
T0849 | DHFR Antifolate Parasite | ||
Pyrimethamine (Pirimecidan) 是一种二氢叶酸还原酶的竞争性抑制剂,用作抗疟药。 | |||
T0148 | DNA/RNA Synthesis Endogenous Metabolite Antifolate | ||
Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物,是一种解毒剂,通常与甲氨蝶呤 (MTX) 联用,以降低 MTX 诱导的毒性。 | |||
T0189L | Apoptosis DHFR DNA/RNA Synthesis Antifolate Autophagy | ||
Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂,用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶,二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM,7.2 nM 和 65 nM。 | |||
T2204 | DHFR Antifolate Antibacterial | ||
Diaveridine (AI3-23935) 是二氢叶酸还原酶的抑制剂,对于野生型 DHFR 的Ki 值为 11.5 nM。它也是一种抗菌剂。 | |||
T0189 | DHFR DNA/RNA Synthesis Antifolate Autophagy | ||
Pemetrexed (LY-231514 Disodium Hydrate) acid 是一种鸟嘌呤衍生的抗肿瘤药物,可结合并抑制胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的 Ki 分别为 1.3 nM、7.2 nM 和 65 nM。 | |||
T7598 | Others Antifolate | ||
Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐,用于治疗心血管疾病、乳腺癌和结肠直肠癌。 | |||
T6120 | Apoptosis DHFR Antifolate TAM Receptor | ||
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T1153 | DHFR DNA/RNA Synthesis Antifolate Antibacterial Antibiotic | ||
Trimethoprim (NSC-106568) 是抑菌抗生素,也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性,可用于尿路感染,肺孢子菌肺炎和志贺氏菌病的研究。 | |||
T17257 | DHFR Antifolate Antibacterial | ||
WR99210 是一种有效的、可口服的且毒性较低的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性,对间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine 的恶性疟原虫株) 以及弓形虫有良好的抑制作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05055 | GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) | Human | HEK293 | ||
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
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TMPJ-00795 | Growth Hormone Protein, Mouse, Recombinant | Mouse | E. coli | ||
Somatotropin(GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
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TMPY-00195 | Growth Hormone Protein, Human, Recombinant (His) | Human | E. coli | ||
Growth Hormone Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 24.7 kDa. Accession number: P01241
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TMPY-00394 | Growth Hormone Protein, Human, Recombinant | Human | E. coli | ||
Growth Hormone Protein, Human, Recombinant is expressed in E. coli. The predicted molecular weight is 22.1 kDa. Accession number: P01241
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