目录号 | 产品详情 | 靶点 | |
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T26636 | Others | ||
Antifolate C2 (AGF 154) 具有抗肿瘤活性,在人肿瘤细胞的生长抑制实验中测得IC为0.14nM。Antifolate C2 可用于研究癌症和自身免疫疾病。 | |||
T26635 | |||
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate carrier (RFC). | |||
T16045 | Antifolate Drug Metabolite | ||
Methotrexate metabolite (DAMPA) (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用,被用作免疫抑制剂。 | |||
T8548 | Histone Methyltransferase Antifolate Histamine Receptor | ||
Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂,具有抗肿瘤活性。它是一种二氨基嘧啶衍生物,可以透过血脑屏障,并通过抑制 HMT 增加脑组胺水平。 | |||
T36692 | DHFR | ||
Fanotaprim 是二氢叶酸还原酶的有效抑制剂,抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。 | |||
T7593 | Antifolate | ||
Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式,是膳食补充剂中生物利用度更高的替代品。 | |||
T7730 | Antifolate | ||
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。 | |||
T6431 | Others Antifolate | ||
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。 | |||
T8003 | Apoptosis Dehydrogenase DNA/RNA Synthesis Antifolate | ||
Methotrexate disodium 是一种叶酸类似物代谢抑制剂,具有免疫抑制剂和抗肿瘤特性,用于类风湿关节炎和研究多种癌症。 | |||
T4382 | Others Dehydrogenase DNA/RNA Synthesis Antifolate Parasite | ||
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05055 | GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) | Human | HEK293 | ||
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
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TMPY-00195 | Growth Hormone Protein, Human, Recombinant (His) | Human | E. coli | ||
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TMPJ-00795 | Growth Hormone Protein, Mouse, Recombinant | Mouse | E. coli | ||
Somatotropin(GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
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TMPY-00394 | Growth Hormone Protein, Human, Recombinant | Human | E. coli | ||
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