目录号 | 产品详情 | 靶点 | |
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T60816 | |||
Protizinic acid 抑制磷脂酶 A2 (PLA2),IC50值为 210 μM。Protizinic acid 是具有抗炎和解热活性的,口服非甾体抗炎剂。 | |||
T61508 | |||
Meloxicam sodium 是一种非甾体类抗炎剂,能够有效抑制COX 的活性,对 COX-2 和 COX-1 的IC50值分别为 0.49 μM 和 36.6 μM。 | |||
T16464 | COX | ||
Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway. It also has significant anti-inflammatory and analgesic effects. Pelubiprofen is an orally active and non-steroidal anti-inflammatory drug and is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity . | |||
T69991 | |||
Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine. | |||
T69422 | |||
Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist and GABAA receptor modulatory properties. | |||
T72669 | |||
Loxoprofenol-SRS 是 Loxoprofen 活性代谢物,是可静脉注射的非甾醇抗炎药。Loxoprofenol-SRS 具有很好的抗炎和缓解疼痛活性。 | |||
T69473 | |||
Pifoxime是一种COX-1/2抑制剂,属于非甾体类抗炎剂(NSAID)。它展示出抗炎活性,可用于神经精神病学研究。 | |||
T27968 | |||
M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss a | |||
T63636 | |||
JTP-117968 是一种选择性的糖皮质激素受体调节剂 (非甾类的 SGRM,IC50值为 6.8 nM),表现出改善的转录抑制/转激活解离效果。 | |||
T68919 | |||
Nabumetone alcohol is the alcohol form of nabumetone, a non-steroidal anti-inflammatory drug (NSAID) that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid, which inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-01640 | MRGPRX2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
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