目录号 | 产品详情 | 靶点 | |
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T4183 | EGFR Tyrosinase | ||
lavendustin A (RG-14355) 是从链霉菌中分离得到的一种天然产物,是细胞渗透性表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂,能抑制血管内皮生长因子诱导的血管生成,阻断 LTPGABA-A 的诱导。 | |||
T5675 | EGFR | ||
Almonertinib hydrochloride (HS-10296 hydrochloride) 是一种 EGFR 激活突变和 T790M 耐药突变的小分子抑制剂,用于非小细胞肺癌的研究,对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性,对野生型的抑制作用较弱。 | |||
T5390 | HER | ||
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种口服生物有效的HER1、HER2和HER4酪氨酸激酶抑制剂(IC50分别为22、32和190 nM),具有潜在的抗肿瘤活性。BMS-599626 Hydrochloride 抑制人表皮生长因子受体HER1, HER2和HER4,从而抑制过表达这些受体的肿瘤细胞的增殖。 | |||
T2630 | Apoptosis EGFR HER | ||
Poziotinib (NOV120101) 是一种不可逆的 HER1/2/4 抑制剂 (IC50s: 3/5/23 nM)。 | |||
T5398 | HER | ||
BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) 是 HER1 和 HER2 的选择性抑制剂(IC50:20 nM 和 30 nM),对 HER4 的效力降低约 8 倍,对 Lck、VEGFR2、c-Kit、MET 等的效力降低 100 倍以上。 | |||
T2610L | HER | ||
BMS-599626 2HCL (AC480 2HCl) 是BMS-599626 衍生物。BMS-599626 是一种可口服且具有选择性的 HER1 和 HER2 双重抑制剂, IC50 分别为 20 和 30 nM。BMS-599626 抑制肿瘤细胞增殖,并有可能增加肿瘤对放疗的反应。 | |||
T8758 | EGFR | ||
Poziotinib hydrochloride 不可逆地抑制 EGFR(HER1 或 ErbB1),包括 EGFR 突变体、HER2 和 HER4,从而抑制过度表达这些受体的肿瘤细胞的增殖。它是一种口服生物可利用的、基于喹唑啉的泛表皮生长因子受体(EGFR 或 HER)抑制剂,具有潜在的抗肿瘤活性。 | |||
T1656 | Apoptosis EGFR VEGFR Autophagy | ||
Vandetanib (ZD6474) 是一种具有口服活性的VEGFR2/KDR 酪氨酸激酶抑制剂,IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1,IC50值分别为110和500 nM。 | |||
T21641 | |||
Vandetanib hydrochloride (D6474 hydrochloride) 是一种有效的,口服的VEGFR2/KDR 酪氨酸激酶抑制剂 (IC50=40 nM)。Vandetanib hydrochloride 对于VEGFR3/FLT4(IC50=110 nM) 和EGFR/HER1(IC50=500 nM)也有抑制作用。 | |||
T64176 | |||
Vandetanib trifluoroacetate (D6474 trifluoroacetate) 是一种口服具有活力的、有效的 VEGFR2/KDR 酪氨酸激酶抑制剂,其 IC50 值为 40 nM。Vandetanib trifluoroacetate 对 VEGFR3/FLT4 和 EGFR/HER1 也表现出抑制作用,他们的 IC50 值分别为 110 nM、500 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00742 | EGFR Protein, Human, Recombinant (His) | Human | HEK293 | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-04529 | EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) | Human | Baculovirus-Insect Cells | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-05612 | EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated | Human | HEK293 | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-05258 | EGFR Protein, Human, Recombinant (Isoform Viii, hFc) | Human | Baculovirus-Insect Cells | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPK-00691 | EGFRVIII Protein, Human, Recombinant (His & Avi) | Human | HEK293 | ||
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
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TMPY-05211 | EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His) | Human | Baculovirus-Insect Cells | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-01043 | EGFR Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-06593 | EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated | Human | HEK293 | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-05637 | EGFR Protein, Human, Recombinant (aa 1-378, His & Avi), Biotinylated | Human | Baculovirus-Insect Cells | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPK-00426 | EGFR Protein, Human, Recombinant (His & Avi) | Human | HEK293 | ||
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
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TMPK-00425 | EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled | Human | HEK293 | ||
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
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TMPY-06549 | EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His) | Human | HEK293 | ||
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPK-00902 | EGFR Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 | ||
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
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TMPK-00427 | EGFR Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 | ||
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
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TMPK-00690 | EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled | Human | HEK293 | ||
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
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TMPK-00689 | EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled | Human | HEK293 | ||
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
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TMPK-00692 | EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 | ||
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
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TMPY-02246 | HB-EGF Protein, Human, Recombinant | Human | Baculovirus-Insect Cells | ||
Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4, and binds to cell surface HSPG. The transmembrane form of HBEGF is a juxtacrine growth and adhesion factor and is uniquely the receptor for diphtheria toxin. Both forms of HB-EGF participate in normal physiological processes and pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HBEGF participates in diverse biological processes, including heart development and maintenance, skin wound healing, eyelid formation, blastocyst implantation, the progression of atherosclerosis, and tumor formation, through the activation of signaling molecules downstream of ErbB receptors and interactions with molecules associated with HBEGF. tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta markedly increased HB-EGF mRNA levels in HUVEC by 12- and 7-fold, respectively, and induction of the gene by TNF-alpha was both dose- and time-dependent.
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