目录号 | 产品详情 | 靶点 | |
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T8639 | GABA Receptor | ||
Phenibut hydrochloride (3-Amino-4-phenylbutyric acid hydrochloride) 是 GABA-B 激动剂,口服有活性,可作用于 GABAB 受体,充当 GABA 类似物。它具有促智 (增强认知) 及抗焦虑的能力。 | |||
T82057 | |||
Iota-conotoxin RXIA是一种作用于电压门控钠通道(Nav1.2, 1.6, 1.7)的激动剂,其在小鼠脑内注射后能够引发青蛙运动神经轴突的重复动作电位以及癫痫样发作。 | |||
T68918 | |||
Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices. It protects against seizures induced by maximal electroshock (MES) in mice. Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus. | |||
T63684 | |||
DAD dichloride 是离子通道阻滞剂,能够阻断电压门控的钾离子通道 (potassium channels))。DAD dichloride 是一种对可见光作出响应的第三代光电开关。DAD dichloride 能够用于研究视觉功能。 | |||
T60492 | |||
Lamotrigine hydrate 是口服有效的抗惊厥剂或抗癫痫剂 ,通过选择性地阻断电压门控Na+通道,稳定突触前神经元膜并抑制谷氨酸释放。Lamotrigine hydrate 可用于研究癫痫、局灶性癫痫等神经性疾病。 | |||
T37670 | |||
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact. | |||
T80185 | Calcium Channel | ||
Huwentoxin I (HWTX-I)为一种肽毒素,针对电压门控钠通道和N型钙通道具有抑制作用。该化合物对大鼠海马神经元和蟑螂DUM神经元的钠离子通道展现出抑制能力,其IC50值分别为66.1 nM和4.80 nM。 | |||
T80851 | |||
VSTx-3是KV通道阻断剂,同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言,其对hNaV1.3通道的IC50为0.19 μM,对hNaV1.7通道的IC50为0.43 μM,对hNaV1.8通道的IC50为0.77 μM。 | |||
T80189 | Sodium Channel | ||
Hainantoxin-IV是针对河豚毒素敏感(TTX-S)电压门控钠通道的特异性拮抗剂。该化合物以His28和Lys32为主要残基与靶标结合,并采用了抑制剂胱氨酸结基序。 | |||
T80455 | Sodium Channel | ||
ω-Conotoxin CVIB为非选择性N型及P/Q型电压门控钙通道(VGCC)拮抗剂,能够抑制背根神经节(DRG)中神经元去极化后激活全细胞VGCC电流,其pIC50值为7.64。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03697 | SCN2B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SCN2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.7 kDa and the accession number is O60939.
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TMPY-03183 | SCN2B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SCN2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is O60939.
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TMPY-02976 | SCN3B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SCN3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q9NY72.
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TMPY-02722 | SCN3B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SCN3B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.5 kDa and the accession number is Q9NY72.
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TMPH-02308 | CACNA2D1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
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TMPH-00780 | CACNA1C Protein, Guinea Pig, Recombinant (His) | Guinea pig | E. coli | ||
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
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TMPY-02245 | SNAP-25 Protein, Human, Recombinant (His) | Human | E. coli | ||
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25 / SUP is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25 / SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25 / SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25 / SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25 / SUP inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25 / SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.
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TMPH-03751 | CYBB Protein, Human, Recombinant (His) | Human | E. coli | ||
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
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TMPY-03615 | CSEN Protein, Human, Recombinant (His) | Human | E. coli | ||
KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS. CSEN is broadly expressed in the brain, thyroid, and other tissues. Diseases associated with KCNIP3 include Alzheimer's Disease and Niemann-Pick Disease, Type C2.
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TMPH-01609 | LGI1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
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TMPH-01394 | GRIN1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 64.6 kDa and the accession number is Q05586.
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TMPH-01744 | NOX1 Protein, Human, Recombinant (His) | Human | E. coli | ||
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 67.7 kDa and the accession number is Q9Y5S8.
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TMPH-00056 | Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) | Anemonia sulcata | P. pastoris (Yeast) | ||
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component).
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TMPJ-00587 | NRCAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptogenesis. It also may play a role in the molecular assembly of the nodes of Ranvier. NrCAM effects are also linked with different recognition processes and signal transduction pathways regulating cell differentiation, proliferation, or migration
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TMPY-01854 | DPP10 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Genetic variations in DPP1 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
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