目录号 | 产品详情 | 靶点 | |
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T2912 | Others Endogenous Metabolite | ||
Ergosterol (Provitamin D2) 是真菌中的主要固醇类,具有抗炎,抗氧化和抗增殖的作用。 | |||
TN7071 | Others | ||
Ergosterol Acetate (Ergosta-5,7,22-trien-3-beta-yl acetate) 是来自红曲霉的 Ergosterol 的乙酸酯衍生物之一。 | |||
TN5288 | |||
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits hACAT-1 and Lp-PLA2 inhibitory effec | |||
TMA1743 | ERK VEGFR p38 MAPK Wnt/beta-catenin Akt JAK CDK JNK STAT Antifection | ||
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to | |||
TN3984 | Others | ||
Ergosterol glucoside is a natural product from Rehmannia glutinosa. | |||
T37858 | |||
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.[1] It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.[1] | |||
T1011 | P450 Hedgehog/Smoothened Antibiotic Autophagy Antifungal | ||
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
T8490 | Antifungal | ||
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物,可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。 | |||
T20625 | Estrogen Receptor/ERR AhR Androgen Receptor Antifungal | ||
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T2305 | P450 Antibiotic Antifungal | ||
Isavuconazole (RO-0094815) 是一种三唑类前药,对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成,导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli | ||
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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TMPH-03017 | CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | Baculovirus | ||
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli | ||
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group.
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