目录号 | 产品详情 | 靶点 | |
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T21365 | |||
Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to leak out. | |||
T40798 | |||
Triflumizole, an imidazole fungicide, acts as an inhibitor of ergosterol biosynthesis. This widely utilized compound effectively controls powdery mildew and scabs on a range of fruits and crops. | |||
T60853 | |||
(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型,用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成,从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂,在体外和体内均具有广谱的抗真菌活性。 | |||
T79551 | |||
Antifungalagent 69 (compound 13),作为一种丁子香酚-咪唑类化合物,对白色念珠菌表现出有效的抗真菌活性,其MIC值为4.6 μM,并未展现显著的细胞毒性。此外,该化合物能够干预真菌的麦角甾醇生物合成路径。 | |||
T74273 | |||
Antifungal agent 52 (compound 6c) 是四唑衍生物。Antifungal agent 52 抑制麦角固醇 的合成。Antifungal agent 52 对白色念珠菌表现出显着的抗真菌活性 Antifungal agent 52 影响白色念珠菌基底细胞膜通透性。 | |||
T1067 | Antibiotic Antifungal | ||
Amphotericin B (NSC-527017) 是一种多烯类抗真菌剂,对许多真菌物种具有广谱活性。Amphotericin B 不可逆地结合麦角甾醇,破坏细胞膜完整性,从而起到抗真菌活性。 | |||
T80777 | |||
Withaphysalin R (化合物 5),一种可从茄科植物中提取的睡茄内酯 (Withanolide),具有麦角固醇框架的甾体内酯。其活性包括细胞毒性、免疫抑制、抗肿瘤、抗炎、抗惊厥及抗氧化等显著生物活性。 | |||
T64105 | |||
Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物,对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用,表现出抗真菌效果。 | |||
T83069 | |||
Antifungalagent 75 (compound 6r) 是针对白色念珠菌有效的抗真菌剂。该化合物通过显著抑制生物膜形成、增加细胞膜通透性、降低麦角甾醇水平并破坏膜结构,从而破坏细胞结构完整性,发挥其抗真菌活性。 | |||
T79467 | |||
Antifungalagent 60(compound 16)是一种抑制麦角甾醇生物合成的广谱抗真菌剂。它能够有效抑制包括7种人类致病真菌、2种耐氟康唑的白色念珠菌分离株以及2种多重耐药的耳念珠菌分离株。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli | ||
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli | ||
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group.
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TMPH-03017 | CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | Baculovirus | ||
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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