目录号 | 产品详情 | 靶点 | |
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T2O2777 | Others Endogenous Metabolite | ||
L-Threonine (threonine) 是人体必需氨基酸,是神经系统的重要氨基酸。L-Threonine 在卟啉和脂肪代谢中也起着重要作用,防止肝脏脂肪堆积。L-Threonine 可用于治疗肠道疾病和消化不良,也可用于缓解焦虑和轻度抑郁。 | |||
T40729 | Endogenous Metabolite | ||
D-Threonine (H-D-Thr-OH) 是酿酒酵母 Saccharomyces cerevisiae 的代谢产物之一。 | |||
T13751 | Others | ||
L-Threonine derivative-1 是乙酰水杨酸-L-苏氨酸酯,具有潜在的镇痛活性。 | |||
T33083 | Others | ||
Lysyl threonine is a dipeptide composed of lysine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T5076 | Others Endogenous Metabolite | ||
L-Allothreonine (L-allo-Threonine) 是内源性代谢产物的一种。 | |||
T21248 | Others | ||
allo-DL-Threonine is a racemic mixture of the D and L isomers of threonine, a polar essential amino acid. | |||
T66425 | |||
DL-Threonine methyl ester hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66425,CAS号为 62076-66-8。 | |||
T66418 | |||
L-Threonine methyl ester hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66418,CAS号为 39994-75-7。 | |||
TP2398 | |||
Palmitoyl dipeptide-7 is a peptide. | |||
T33794 | Others | ||
O-Mannopyranosylthreonine is a bioactive chemical. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01059 | BMPR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873.
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TMPH-01617 | SDS Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
SDS Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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TMPY-04407 | LOK Protein, Human, Recombinant (His) | Human | E. coli | ||
Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste2 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK1 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK1 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk1 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
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TMPY-04466 | STK40 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ESCs markedly reduces ExEn differentiation in vitro. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFκB-mediated gene transcription. Similarly, overexpression of STK40 inhibits NFκB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.
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TMPY-04374 | MST4 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently transfected cells or stable cell lines, and thus is biologically active in the activation of the MEK/ERK pathway mediating cell growth and transformation. Further, MST4 kinase activity is stimulated significantly by epidermal growth factor receptor (EGFR) ligands, which are known to promote the growth of certain cancer cells. Accordingly, MST4 has a potential role in signal transduction pathways involved in cancer progression. Three alternatively spliced isoforms of MST4 have been isolated, and isoform 3 lacks an exon encoding kinase domain and may function as a dominant-negative regulator of the MST4 kinase.
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TMPH-02899 | VRK1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
VRK1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q80X41.
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TMPH-03458 | STE11 Protein, S. cerevisiae, Recombinant | Saccharomyces cerevisiae | E. coli | ||
Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases. STE11 Protein, S. cerevisiae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.5 kDa and the accession number is P23561.
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TMPY-04468 | STK16 Protein, Human, Recombinant (His & NusA) | Human | E. coli | ||
Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 / MPSK1 is a unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 / MPSK1 is a protein kinase that acts on both serine and threonine residues. STK16 / MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 / MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 / MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.
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TMPY-04398 | MST1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
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TMPH-01685 | MAST4 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
MAST4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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TMPH-00499 | PPP1CA Protein, Canine, Recombinant (His & Myc) | Canine | E. coli | ||
PPP1CA Protein, Canine, Recombinant (His & Myc) is expressed in E. coli.
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TMPH-02097 | PPP5C Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
PPP5C Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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TMPH-02098 | PPP1CB Protein, Human, Recombinant (His) | Human | E. coli | ||
PPP1CB Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-00340 | ATG1 Protein, Candida glabrata, Recombinant (His) | Candida glabrata | E. coli | ||
ATG1 Protein, Candida glabrata, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.4 kDa and the accession number is Q6FL58.
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TMPH-03456 | CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | Baculovirus Insect Cells | ||
CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.1 kDa and the accession number is P43568.
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TMPH-03457 | CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) | Saccharomyces cerevisiae | E. coli | ||
CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P43568.
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TMPH-01405 | GSK3B Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
GSK3B Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.7 kDa and the accession number is P49841.
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TMPH-02335 | RIOK3 Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
RIOK3 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 62.7 kDa and the accession number is O14730.
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TMPJ-00944 | PPP1CC Protein, Human, Recombinant (His) | Human | E. coli | ||
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1CC may play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.
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TMPH-02093 | RIOK3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
RIOK3 Protein, Human, Recombinant (His) is expressed in Baculovirus.
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TMPY-05095 | RAF1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-04424 | MST3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
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TMPH-02096 | PPP2CA Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
PPP2CA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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TMPH-01995 | RAF1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
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TMPH-02088 | LATS1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
LATS1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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TMPY-02198 | ILKAP Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin-linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase ( ILK ) plays key roles in a variety of cell functions, including cell proliferation, adhesion, and migration. Within the cell, ILK localizes to multiple sites, including the cytoplasm, focal adhesion complexes that mediate cell adhesion to extracellular substrates, as well as cell-cell junctions in epidermal keratinocytes. Nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is sensitive to inhibition by ILKAP.
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TMPH-03022 | PstP Protein, Mycobacterium tuberculosis, Recombinant | Mycobacterium tuberculosis | E. coli | ||
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. PstP Protein, Mycobacterium tuberculosis, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.3 kDa and the accession number is P9WHW4.
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TMPH-02090 | PKN1 Protein, Human, Recombinant (His) | Human | E. coli | ||
PKN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.5 kDa and the accession number is Q16512.
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TMPH-03021 | PstP Protein, Mycobacterium tuberculosis, Recombinant (His) | Mycobacterium tuberculosis | E. coli | ||
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection.
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TMPH-02094 | STK11 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
STK11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.3 kDa and the accession number is Q15831.
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TMPH-02091 | PAK1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
PAK1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-02087 | STK38L Protein, Human, Recombinant (His) | Human | E. coli | ||
Involved in the regulation of structural processes in differentiating and mature neuronal cells. STK38L Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.5 kDa and the accession number is Q9Y2H1.
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TMPH-02647 | FAM20C Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells | ||
FAM20C Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 60.4 kDa and the accession number is Q5MJS3.
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TMPH-03362 | PKM2 Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus Insect Cells | ||
PKM2 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 61.8 kDa and the accession number is P11980.
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TMPH-02871 | PKM2 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells | ||
PKM2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 61.8 kDa and the accession number is P52480.
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TMPH-00839 | RIPK3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
RIPK3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.9 kDa and the accession number is Q9Y572.
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TMPH-02877 | RIPK3 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
RIPK3 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the accession number is Q9QZL0.
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TMPH-02876 | RIPK1 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway. Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis. RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis. In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1. Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis. Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8. In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Required for ZBP1-induced NF-kappa-B activation in response to DNA damage.
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TMPH-03363 | PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) | Rat | E. coli | ||
PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.8 kDa and the accession number is P11980.
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TMPH-02007 | RIPK1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
RIPK1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q13546.
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TMPH-02872 | PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli | ||
PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.8 kDa and the accession number is P52480.
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TMPH-02009 | RIPK3 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
RIPK3 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is Q9Y572.
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TMPH-01693 | MAP3K14 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
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TMPH-01539 | ILK Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
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TMPY-00683 | BMPR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
BMPR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is Q13873.
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TMPH-01531 | IKBKB Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death. Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus.
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TMPH-01532 | IKBKB Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death. Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus.
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TMPJ-00325 | BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells | ||
Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2).
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TMPH-02008 | RIPK2 Protein, Human, Recombinant (His) | Human | E. coli | ||
RIPK2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.2 kDa and the accession number is O43353.
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TMPH-01171 | CDK5 Protein, Human, Recombinant | Human | E. coli | ||
CDK5 Protein, Human, Recombinant is expressed in E. coli.
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