目录号 | 产品详情 | 靶点 | |
---|---|---|---|
TN5033 | IL Receptor Caspase Prostaglandin Receptor | ||
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
TN3325 | IL Receptor TNF | ||
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi | |||
TN2511 | IL Receptor PARP ROS MAPK Caspase JAK JNK STAT | ||
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN3870 | Others | ||
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c | |||
T60590 | |||
Chloropyramine 是竞争性可逆 H1 受体拮抗剂,可用于过敏性疾病的研究,例如结膜炎和支气管哮喘。Chloropyramine 表现出抗乳腺癌活性。 | |||
T62691 | |||
Syk Inhibitor II dihydrochloride dihydrate 是一种高度选择性的、有效的、ATP 竞争性 Syk 抑制剂 (IC50: 41 nM)。Syk Inhibitor II dihydrochloride dihydrate 抑制 RBL 细胞释放 5-HT (IC50: 460 nM),对其他激酶的作用较弱。Syk Inhibitor II dihydrochloride dihydrate 表现出抗过敏作用。 | |||
T74118 | |||
Roxatidine 是 Roxatidine acetate 的活性代谢产物,是组胺 H2受体拮抗剂。Roxatidine 是抗溃疡药,抑制组胺释放(从而抑制质子分泌)并抑制炎症和血管生成的重要标志物 VEGF-1 的产生。具有抗过敏性炎症作用。 | |||
T73666 | |||
Proglumetacin 是一种口服有效的环加氧酶 (cyclo-oxygenase) 抑制剂。Proglumetacin 可以抑制 SARS-CoVMpro(新冠病毒的主要蛋白酶),其 AC50为 8.9 μM。Proglumetacin 具有抗炎活性,可用于炎症(如类风湿关节炎、过敏性气囊炎)的研究。 | |||
T36713 | |||
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB). | |||
TN4489 | ERK cAMP TNF NF-κB MAPK COX HIF Prostaglandin Receptor JNK STAT | ||
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPJ-00323 | Nectin-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.
|
|||||
TMPY-06383 | Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 38.80 kDa and the accession number is Q92692-2.
|
|||||
TMPY-03036 | Nectin-2 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Nectin-2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is Q9ESS6.
|
|||||
TMPY-00747 | Nectin-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
|
|||||
TMPY-06295 | Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 64.08 kDa and the accession number is Q92692-2.
|
|||||
TMPK-00293 | Nectin-2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC.
|
|||||
TMPY-00748 | Nectin-2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
|
|||||
TMPY-02561 | Nectin-2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Nectin-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q0MSE5.
|
|||||
TMPY-01150 | Nectin-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Nectin-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P32507-1.
|
|||||
TMPY-00746 | Nectin-2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.3 kDa and the accession number is Q92692-2.
|