目录号 | 产品详情 | 靶点 | |
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T28149 | |||
NDM-1 inhibitor-2 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1). | |||
T69064 | |||
Clavulanic Acid Methyl Ester is a substituted Clavulanic acid and β-lactamase inhibitor. | |||
T39288 | |||
Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes. | |||
T28148 | |||
NDM-1 inhibitor-1 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1). | |||
T75294 | |||
Nafcillin sodium 是一种抗生素,是可逆的β-lactamase 抑制剂。Nafcillin sodium 可用于葡萄球菌感染的研究。 | |||
T75391 | |||
Penicillinase 是一种 β-内酰胺酶。β-内酰胺酶通过水解特征性四元 β-内酰胺环的肽键使抗生素失效,从而使 β-内酰胺抗生素失活。 | |||
T70774 | |||
Clavicoronic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. | |||
T21384 | |||
Dicloxacillin (INN), a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins. | |||
T75223 | |||
RDR 02308 是 TLR4-MyD88结合抑制剂,可抑制全长β-lactamase。 | |||
T13395 | Others | ||
Zidebactam sodium salt is a potent inhibitor of β-lactamase, and also is an inhibitor of penicillin-binding protein2 (PBP2)(IC50 of 0.26 μg/mL). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-01157 | LACTB2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is expressed at high levels and annotates structural defects or features in 4 cDNA clones. LACTB2 proteins are expected to have hydrolase activity and metal ion-binding functions. LACTB2 protein is found to localize in mitochondrion. Other functions of LACTB2 is yet unknown.
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TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa and the accession number is P24735.
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TMPH-00588 | Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | P. pastoris (Yeast) | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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TMPH-03474 | Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant | Salmonella typhimurium | E. coli | ||
Has cefotaxime-hydrolyzing activity. Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28.4 kDa and the accession number is P74841.
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TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Hydrolyzes both carbenicillin and oxacillin. Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.5 kDa and the accession number is P14489.
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TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P52699.
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TMPH-00584 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | P. pastoris (Yeast) | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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