目录号 | 产品详情 | 靶点 | |
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T74849 | |||
EBL-3183为一种吲哚-2-羧酸盐,作为有效的金属-β-内酰胺酶(MBL)抑制剂。它通过可逆结合、非共价及竞争性作用抑制NDM-1,其pIC50值为7.7。 | |||
T61204 | |||
FPI-1465 是丝氨酸-β-内酰胺酶和青霉素结合蛋白 (PBP) 的双重抑制剂。FPI-1465 抑制PBP2,IC50为 1.0 μg/mL。FPI-1465 作用于 β-内酰胺酶 CTX-M-15 和 OXA-48,Kd 分别为 0.011 和 5.3 μM。 | |||
T68866 | |||
Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics unless this enzyme is inhibited. . | |||
T38940 | |||
FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes. It has Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. Additionally, FPI-1523 inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity. | |||
T73668 | |||
Sanfetrinem (GV104326) sodium,作为一种β-内酰胺酶稳定的抗生素(antibiotic),对革兰氏阳性菌和革兰氏阴性菌展现出广泛的抗菌活性。 | |||
T38020 | |||
O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)199-207(2018) | |||
T60383 | |||
Captopril (SQ 14225) hydrochloride 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂,IC50值为0.025 μM,已广泛应用于高血压和充血性心力衰竭的研究。Captopril hydrochloride 也是 NDM-1抑制剂,IC50值为 7.9 μM。 | |||
T69266 | |||
Cefcanel is a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel is active against the species E. coli, K. aerogenes and Proteus mirabilis; H. influenzae and M. catarrhalis has reasonable susceptibility. Cefcanel inhibits 90% of S. aureus strains at 2 µg/ml, irrespective of the presence of a β-lactamase. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-01157 | LACTB2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is expressed at high levels and annotates structural defects or features in 4 cDNA clones. LACTB2 proteins are expected to have hydrolase activity and metal ion-binding functions. LACTB2 protein is found to localize in mitochondrion. Other functions of LACTB2 is yet unknown.
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TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli with N-terminal 6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa. Accession number: P24735
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TMPH-00588 | Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | Yeast | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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TMPH-03474 | Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant | Salmonella typhimurium | E. coli | ||
Has cefotaxime-hydrolyzing activity.
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TMPH-00584 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
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TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Hydrolyzes both carbenicillin and oxacillin.
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TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | Yeast | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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