目录号 | 产品详情 | 靶点 | |
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T0611 | Others | ||
Vanillylmandelic acid (4-Hydroxy-3-methoxymandelic acid) 是儿茶酚胺、肾上腺素和去甲肾上腺素代谢的最终产物,常用于帮助诊断嗜铬细胞瘤,以及其升高与抑郁症状有关。 | |||
T2S1778 | Others | ||
DL-Goitrin 也称为 (R,S)-Goitrin,由 epigoitrin (R-Goitrin) 和告依春 (S-Goitrin) 两种异构体组成,是板蓝根的成分。 | |||
T67810 | Norepinephrine | ||
Tampramine 是一种选择性去甲肾上腺素再摄取抑制剂,对肾上腺素能、组胺能和毒蕈碱受体显示出较低的亲和力。Tampramine 是治疗强迫游泳测试(FST)抑郁症的候选化合物。 | |||
T60325 | 5-HT Receptor Norepinephrine | ||
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2]. | |||
T7783 | Others | ||
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 是一种单胺类神经递质,已被研究其调节各种神经递质活性的潜力,包括血清素、多巴胺和去甲肾上腺素,还研究了其作为5-HT2A 受体激动剂的潜力。 | |||
T68095 | Dopamine Receptor Norepinephrine | ||
Losulazine 是一种新型的降压化合物。其确切的作用机制尚未确定,但其降压作用取决于完整的、功能性交感神经系统的存在。 | |||
T0948 | Adrenergic Receptor | ||
Adrenalone hydrochloride (Adrenalone HCl) 是一种多巴胺β氧化酶 (dopamine β oxidase) 抑制剂,结构与去甲肾上腺素转运蛋白 (NET) 配体相似,IC50=36.9 μM。它是一种肾上腺素能 (adrenergic) 激动剂,用作局部血管收缩剂和止血剂。 | |||
T21428 | Histamine Receptor | ||
Mianserin 是H1受体反向激动剂,是四环抗抑郁药(TeCA)治疗家族中的一种精神活性化合物,具有抗抑郁、抗焦虑、止吐、促氧、催眠和抗组胺作用,可作为去甲肾上腺素和特定的血清素联合用药能治疗抑郁症。 | |||
T1644 | Ferroptosis Dopamine Receptor 5-HT Receptor Endogenous Metabolite | ||
Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺,由二羟基苯丙氨酸脱羧形成,是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用,有促进血管生成活性。 | |||
T1189 | Serotonin Transporter Norepinephrine | ||
Milnacipran hydrochloride (Savella) 是一种5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),可用于纤维肌痛的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03852 | Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.
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TMPY-02948 | SULT1A3 Protein, Human, Recombinant (His) | Human | E. coli | ||
SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. It is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). SULT1A3 is expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. SULT1A3 is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
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