目录号 | 产品详情 | 靶点 | |
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T60276 | |||
Cyclocreatine phosphate 是一种抗肿瘤剂。Cyclocreatine phosphate 是环肌酸 (CCr) 的活性形式,环肌酸是肌酸激酶的底物类似物。环肌酸及其水溶性衍生物 Cyclocreatine phosphate (CCrP) 是有效的心脏保护药物。Cyclocreatine phosphate 可用于癌症研究。 | |||
T77201 | |||
Rutin (Rutoside) trihydrate 是多功能天然黄酮苷,展现出抗氧化、抗炎、抗糖尿病及抗癌效果。此外,该化合物还具有心脏保护和神经保护活性。 | |||
T37379 | Akt PI3K | ||
Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素 ,是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤,抑制咪喹莫特诱导的银屑病样皮肤炎症。 | |||
T81485 | |||
Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌,并促进胰岛素释放。此外,Phoenixin-14 TFA保护小鼠免受缺血/再灌注(IR)伤害,通过降低ROS、提高GSH减缓氧化应激。 | |||
T11731L | Others Calcium Channel | ||
JTV-519 Formate 是一种 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂,同时也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 Formate 显示出抗心律失常作用,是一种心脏保护剂。 | |||
T62288 | |||
AD013 是一种双重的 cACE 和 NEP 抑制剂。AD013 是通过 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成。AD013 具有潜力提供强效抗高血压和心脏保护作用。 | |||
T62831 | |||
AD012 是一种 cACE/NEP 的双重抑制剂。AD012 利用先前报道的 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成。AD012 具有潜力提供强效抗高血压和心脏保护作用。 | |||
TP1965 | |||
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop | |||
T8291 | Others | ||
2-Carene 是一种天然存在的双环单萜,存在于许多精油中,如松树、雪松和柏树。它被发现具有抗炎、抗真菌和抗菌活性,以及抗氧化、抗肿瘤和抗过敏活性,还有神经保护、心脏保护和肝脏保护作用。 | |||
TP1966 | |||
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.
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TMPY-01606 | Kininogen 1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Kininogen 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.5 kDa and the accession number is D3YTY9.
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TMPY-01598 | Kininogen 1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Kininogen 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is P01042-1.
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