目录号 | 产品详情 | 靶点 | |
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T75531 | |||
Ladanetin-6-O-β-D-glucopyranoside, 一种活性类黄酮, 具备抗氧化功能,并可应用于心脏保护研究。 | |||
T61540 | |||
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1]. | |||
TN1642 | BCL PARP Caspase | ||
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells. | |||
T28400 | |||
Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-regulates their mRNA transcription a | |||
T78092 | PI3K | ||
UCL-TRO-1938为一种有效的PI3Kα变构激活剂,EC50约60 μM。该化合物能够诱导细胞增殖,并具备心脏保护及神经再生功能。 | |||
T76191 | |||
GLP-1(28-36)amide TFA,为GLP-1 C-端九肽段,主要通过中性内肽酶(NEP)裂解GLP-1生成。该化合物作为一种抗氧化剂,能靶向线粒体,抑制线粒体通透性转变(MPT),显示出抗糖尿病和心脏保护的功效。 | |||
T80070 | PKC | ||
PKCβII Peptide Inhibitor I 为一种特定的PKCβII抑制剂。在大鼠心脏缺血/再灌注损伤模型中,该化合物显著表现出心脏保护效应,并能有效预防血管内皮功能障碍。 | |||
T81956 | |||
Ladanetin-6-O-β-(6′′-O-acetyl)glucoside 是一种从甘青青兰 (Dracocephalum tanguticum) 全株中提取的黄酮化合物,具备抗氧化特性。该化合物能够保护H9c2心肌细胞免受Doxorubicin(DOX)引起的细胞毒性。 | |||
TN1431 | Others | ||
Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti | |||
T63160 | |||
AD011 是一种双重的 cACE/NEP 抑制剂。AD011 是通过先前报道的 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成的。AD011 显示出提供高效抗高血压和心脏保护作用的潜力。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.
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TMPY-01606 | Kininogen 1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Kininogen 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.5 kDa and the accession number is D3YTY9.
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TMPY-01598 | Kininogen 1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Kininogen 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is P01042-1.
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