目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T77816 | |||
Deruxtecananalog 2(示例9 P3)是一种含活性分子-linker的Deruxtecan类似物,由Camptothecin(一种对多种癌症如结直肠癌、乳腺癌、肺癌和卵巢癌具有抗肿瘤活性的Topo I抑制剂)和linker组成,主要用于开发针对EGFR2的抗体药物偶联物(ADC)活性分子。 | |||
T82512 | |||
EB1 peptide (Penetrating analog) 为一种Penetratin衍生的CPP(两亲性细胞穿透肽),展现了在细胞内药物输送领域的应用潜力。 | |||
T10891 | P450 | ||
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. | |||
T61970 | |||
Kolavenic acid analog (KAA) 是具有抗癌活性的化合物。对过量生产HSET 的酵母细胞,Kolavenic acid analog 具有很强的活性。在含有超数中心体和高 HSET 水平的人类癌细胞中,Kolavenic acid analog 可以抑制中心体聚集。 | |||
T10793 | Chk | ||
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor. | |||
T13263 | COX | ||
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T25322 | |||
Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity. | |||
T32648 | |||
Leptophos oxon is a phosvel analog-oxygen substituting sulfur. | |||
T10658 | HIV Protease | ||
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid. | |||
T25244 | |||
Chloromethylketone methotrexate is an analog of methotrexate and a potential antitumor. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPH-03036 | Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc) | Naja atra | E. coli | ||
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.
|
|||||
TMPH-00645 | Lactose permease Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. Lactose permease Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 34.4 kDa and the accession number is P02920.
|
|||||
TMPJ-00871 | BAR Protein, S. hygroscopicus, Recombinant | Streptomyces hygroscopicus | E. coli | ||
Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acetylate other L-amino acids or structurally similar molecules. L-PPT is a glutamate analog that can inhibit glutamine synthetase activity in plants, resulting in the accumulation of ammonia to toxic levels and impairment of photosynthesis. The introduction of a PAT gene into a plant genome can confer resistance to glufosinate herbicide during post-emergent applications.
|
|||||
TMPH-03038 | Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) | Naja kaouthia | E. coli | ||
Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
|