T24116
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GSM-1 is a modulator of γ-Secretase. |
T27500
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GSK-B, a potent γ-secretase modulator, decreases Aβ42, increases Aβ38 with no effect on Aβ40 levels. |
T10211
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Others
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Aβ42-IN-1,化合物 1v,是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的情况下,在培养细胞中有效降低Aβ42水平,IC50值为 0.091 μM。Aβ42-IN-1 显示出良好的药代动力学特征。 |
T24210
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JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch. |
T28735
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SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease. |
T24621
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PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders. |
T11903
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Others
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LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575. |
T63149
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LY-411575 isomer 2 是 LY411575 的异构体。其中 LY411575 是一种高效的 γ-secretase 抑制剂。 |
T63150
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LY-411575 isomer 3 是 LY411575 的异构体。其中 LY411575 是一种高效的 γ-secretase 抑制剂。 |
T24720
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RO-57-Bpyne is a γ-secretase modulator photoaffinity probe. It also can be exploited to reduce levels of pathogenic Aβ species. It acts by identifying distinct allosteric binding sites on presenilin. |