目录号 | 产品详情 | 靶点 | |
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T75241 | |||
Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂,对GT1a 和 GT1b 复制子抑制作用显著,其EC50值仅为34 pM 和 4 pM。此外,Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro, IC50 为1.62 μM。 | |||
T71059 | |||
Ranitidine bismuth citrate 为一种口服活性的组胺H2受体(Histamine H2-receptor)拮抗剂,其IC50值为3.3 μM,对SARS-CoV-2感染细胞显示高选择性。该化合物还是治疗幽门螺杆菌(Helicobacter Pylori)感染的常用试剂,其MIC90为16 ng/L。 | |||
T73341 | |||
Quipazine 是一种5-HT 激动剂,取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的Ki 值为 1.4 nM。Quipazine 对SARS-CoV-2具有抗病毒活性,EC50值为 31.64 μM。Quipazine 在外周模型中表现为 5-HT3R 的激动剂,可用于神经疾病研究。 | |||
T75093 | |||
STINGagonist-25 (CF505) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING,增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。 | |||
T76336 | |||
Astodrimer (SPL7013 free base) 是一种体积较大(3-4 nm, ~ 16.5 kDa)、带负电荷、高度分支化的树状高分子,有效抑制并杀灭多种病毒,包括 SARS-CoV-2、HIV-1、HSV-1、HSV-2、HPV 等,具有广谱的抗病毒和杀病毒活性,同时展现出抗菌特性。 | |||
T62991 | |||
Mpro/PLpro-IN-1 (Compound 29) 是一种双重作用的 SARS-CoV-2 蛋白酶抑制剂。Mpro/PLpro-IN-1 也是一种 Mpro/PLpro 的有效抑制剂,对 M pro 具有微摩尔抑制作用(IC50:1.72 μM),对 PL pro 具有亚微摩尔抑制作用(IC50:0.67 μM)。 | |||
T62479 | |||
3CPLro-IN-1 (compound A17) 是一种有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 5.65 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是一种病毒复制中不可或缺的蛋白质,是一种有吸引力的、对抗 COVID-19 的药物靶点。 | |||
T75092 | |||
STINGagonist-24 (CF504) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING,增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。 | |||
T75091 | |||
STINGagonist-23 (CF502) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING,增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和 CCL-5的水平。STINGagonist-23 表现出抗 SARS-CoV 系列的活性。 | |||
TMIH-0146 | |||
Chloroquine-d5 是 Chloroquine 的氘代化合物。Chloroquine 的 CAS 号为 54-05-7。Chloroquine 是一种自噬和 Toll 样受体抑制剂。 氯喹是一种抗疟疾和抗炎剂,广泛用于治疗疟疾和类风湿性关节炎。它在体外控制 SARS-CoV-2 (COVID-19) 感染方面非常有效,EC50 为 1.13 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02870 | SARS-CoV Nucleocapsid Protein (His) | SARS | Baculovirus Insect Cells | ||
SARS-CoV Nucleocapsid Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 47.5 kDa and the accession number is Q6S8E1.
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TMPY-05817 | SARS-CoV Spike/RBD Protein (His), Biotinylated | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike/RBD Protein (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q5DIC5.
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TMPY-03224 | SARS-CoV Spike/RBD Protein (His) | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike/RBD Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q5DIC5.
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TMPY-04177 | SARS-CoV Spike/RBD Protein (rFc) | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike/RBD Protein (rFc) is expressed in Baculovirus insect cells with rFc tag. The predicted molecular weight is 50.2 kDa and the accession number is Q5DIC5.
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TMPY-05701 | SARS-CoV Spike/RBD Protein (mFc) | SARS | HEK293 Cells | ||
SARS-CoV Spike/RBD Protein (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.40 kDa and the accession number is Q5DIC5.
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TMPJ-01450 | SARS-CoV-2 Helicase Protein (His & MBP) | SARS-CoV-2 | E. coli | ||
The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom’s syndrome, Werner’s syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function.
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TMPY-06372 | SARS-CoV Spike RBD Protein (mFc), Biotinylated | SARS | HEK293 Cells | ||
SARS-CoV Spike RBD Protein (mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.49 kDa and the accession number is AAX16192.1.
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TMPY-03988 | SARS-CoV Spike/S1 Protein (His) | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike/S1 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 74.4 kDa and the accession number is Q5DIC5.
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TMPY-05722 | SARS-CoV Spike S2 Protein (His) | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike S2 Protein (His) is expressed in Baculovirus insect cells. The predicted molecular weight is 59.65 kDa and the accession number is NP_828851.1.
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TMPY-05702 | SARS-CoV Spike/S1 Protein (mFc) | SARS | HEK293 Cells | ||
SARS-CoV Spike/S1 Protein (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 99.40 kDa and the accession number is Q5DIC5.
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TMPJ-01426 | SARS-CoV-2 NSP2 Protein (His) | SARS-CoV-2 | E. coli | ||
The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
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TMPY-05699 | SARS-CoV Spike/S1 Protein (His), Biotinylated | SARS | Baculovirus Insect Cells | ||
SARS-CoV Spike/S1 Protein (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 74.4 kDa and the accession number is Q5DIC5.
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TMPJ-01425 | SARS-CoV-2 NSP1 Protein (His) | SARS-CoV-2 | E. coli | ||
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
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TMPY-06204 | SARS-CoV (Isolate Tor2) Spike RBD Protein (His & Avi), Biotinylated | SARS | HEK293 Cells | ||
SARS-CoV (Isolate Tor2) Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.4 kDa and the accession number is NP_828851.1.
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TMPJ-01427 | SARS-CoV-2 NSP7 Protein (His) | SARS-CoV-2 | E. coli | ||
The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps). The four proteins nsp7 to nsp10, which are conserved among all CoVs but have no functional homologs outside of the Coronaviridae, are translated as part of the viral polyproteins pp1a and pp1ab, and the mature proteins are released by the action of the SARS-CoV protease nsp5. Hexadecamer of nsp7 and nsp8 may possess dsRNA-binding activity. SARS-CoV 2 nonstructural protein 7 (nsp7) is of interest for its potential roles in the transcription and replication of the positive-stranded viral RNA genome.
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TMPJ-01428 | SARS-CoV-2 NSP8 Protein (His) | SARS-CoV-2 | E. coli | ||
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.
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TMPY-06176 | SARS-CoV (Isolate Tor2) Spike S1+S2 Protein (S577A, His), Biotinylated | SARS | Baculovirus Insect Cells | ||
SARS-CoV (Isolate Tor2) Spike S1+S2 Protein (S577A, His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 132.58 kDa and the accession number is NP_828851.1.
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TMPJ-01429 | SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) | SARS-CoV-2 | E. coli | ||
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.
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TMPY-05718 | SARS-CoV (Isolate Tor2) Spike S1+S2 ECD Protein (S577A, His) | SARS | Baculovirus Insect Cells | ||
SARS-CoV (Isolate Tor2) Spike S1+S2 ECD Protein (S577A, His) is expressed in Baculovirus insect cells. The predicted molecular weight is 132.58 kDa and the accession number is NP_828851.1.
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TMPK-01412 | HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
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TMPK-01416 | HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells | ||
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
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TMPY-05679 | SARS-CoV-2 Spike RBD Protein (hFc) | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (hFc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 51.8 kDa and the accession number is A0A6G7K2L4.
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TMPK-00265 | SARS-COV-2 Nucleocapsid Protein (His & Avi), Biotinylated | SARS-CoV-2 | E. coli | ||
Nucleocapsid protein (N) is the major viral structural component; its main function is to protect and encapsidate the viral RNA forming viral RNP complex. It is encoded by the S segment vRNA and is abundantly expressed in the cytoplasm of infected cells. SARS-COV-2 Nucleocapsid Protein (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 48.9 kDa and the accession number is P0DTC9.
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TMPY-06071 | SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 108.3 kDa and the accession number is YP_009725307.1.
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TMPK-00911 | SARS Spike RBD Protein (His & Avi) | SARS | HEK293 Cells | ||
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number is P59594.
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TMPY-05664 | SARS-CoV-2 Nucleocapsid Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 Nucleocapsid Protein (His) is expressed in Baculovirus insect cells. The predicted molecular weight is 47.08 kDa and the accession number is P0DTC9.
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TMPK-00912 | SARS Spike RBD Protein (His & Avi), Biotinylated | SARS | HEK293 Cells | ||
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number is P59594.
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TMPY-06416 | SARS-CoV-2 NSP8 Protein | SARS-CoV-2 | E. coli | ||
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is YP_009725304.1.
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TMPY-06086 | SARS-CoV-2 Helicase Protein (His) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 Helicase Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 67.8 kDa and the accession number is YP_009725308.1.
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TMPY-05663 | SARS-CoV-2 Spike RBD Protein (mFc) | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (mFc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 51.5 kDa and the accession number is A0A6G7K2L4.
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TMPK-01384 | SARS PLpro/papain-like protease Protein (His) | SARS | E. coli | ||
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 36.91 kDa and the accession number is AAX16193.1.
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TMPY-05681 | SARS-CoV-2 Spike RBD Protein (rFc) | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (rFc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.3 kDa and the accession number is A0A6G7K2L4.
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TMPY-05695 | SARS-CoV-2 Nucleocapsid Protein (His), Biotinylated | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 Nucleocapsid Protein (His), Biotinylated is expressed in Baculovirus insect cells. The predicted molecular weight is 47.08 kDa and the accession number is P0DTC9.
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TMPY-06113 | SARS-CoV-2 Nucleocapsid CTD Protein (His) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 Nucleocapsid CTD Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.2 kDa and the accession number is P0DTC9.
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TMPY-06012 | SARS-CoV-2 NSP10 Protein | SARS-CoV-2 | E. coli | ||
NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is YP_009725306.1.
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TMPY-05749 | SARS-CoV-2 NSP8 Protein (Avi) | SARS-CoV-2 | E. coli | ||
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession number is YP_009725304.1.
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TMPY-06009 | SARS-CoV-2 NSP7 Protein | SARS-CoV-2 | E. coli | ||
NSP7 is conserved within the coronaviridae. NSP7 is a component of the coronavirus replicase polyprotein to comprise a repilication complex. NSP7 has been shown to interact with NSP10 and NSP1 which indicate that NSP7 has a founction in coronavirus-specific RNA replication mechanisms.
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TMPK-00910 | SARS Spike S1 Protein (His & Avi) | SARS | HEK293 Cells | ||
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number is P59594.
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TMPY-06011 | SARS-CoV-2 NSP10 Protein (His) | SARS-CoV-2 | E. coli | ||
NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 15.7 kDa and the accession number is YP_009725306.1.
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TMPY-05820 | SARS-CoV-2 NSP3 Protein (His) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 NSP3 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 19.87 kDa and the accession number is YP_009725299.1.
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TMPJ-01431 | SARS-CoV-2 Papain-Like Protease Protein | SARS-CoV-2 | E. coli | ||
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
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TMPK-00908 | SARS Spike S1 Protein (hFc & Avi) | SARS | HEK293 Cells | ||
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number is P59594.
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TMPY-05668 | SARS-CoV-2 Spike RBD Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 Spike RBD Protein (His) is expressed in Baculovirus insect cells. The predicted molecular weight is 26.54 kDa and the accession number is A0A6G7K2L4.
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TMPY-06114 | SARS-CoV-2 Nucleocapsid NTD Protein (His) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 Nucleocapsid NTD Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P0DTC9.
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TMPK-00263 | SARS-COV-2 Nucleocapsid Protein (His & Avi) | SARS-CoV-2 | E. coli | ||
Nucleocapsid protein (N) is the major viral structural component; its main function is to protect and encapsidate the viral RNA forming viral RNP complex. It is encoded by the S segment vRNA and is abundantly expressed in the cytoplasm of infected cells. SARS-COV-2 Nucleocapsid Protein (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 48.9 kDa and the accession number is P0DTC9.
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TMPY-05693 | SARS-CoV-2 Methyltransferase/ME Protein (His) | SARS-CoV-2 | E. coli | ||
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design in an expanding Coronavirus outbreak setting, such as COVID-19. Targeting the 2'O-methylation pathway on SARS-CoV replication and pathogenesis can be the treatment options for vaccine and anti-viral drug development which can against SARS-CoV-2,SARS-CoV, MERS-CoV or other RNA and DNA viruses.
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TMPY-05667 | SARS-CoV-2 Spike S1 Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 Spike S1 Protein (His) is expressed in Baculovirus insect cells. The predicted molecular weight is 76.45 kDa and the accession number is A0A6G7K2L4.
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TMPY-06189 | SARS-CoV-2 Nucleocapsid Protein (A220V, His) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 Nucleocapsid Protein (A220V, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
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TMPY-05712 | SARS-CoV-2 NSP9 Protein (His & Avi) | SARS-CoV-2 | E. coli | ||
SARS-CoV-2 NSP9 Protein (His & Avi) is expressed in E. coli expression system. The predicted molecular weight is 15.46 kDa and the accession number is YP_009725305.1.
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TMPK-00909 | SARS Spike S1 Protein (hFc & Avi), Biotinylated | SARS | HEK293 Cells | ||
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number is P59594.
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