SARS-CoV-2 NSP1 Protein (His)

The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.

规格	价格/CNY		数量
10 μg	￥ 980	5日内发货
50 μg	￥ 2,960	5日内发货
500 μg	￥ 15,800	5日内发货
1 mg	￥ 23,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 980

5日内发货

50 μg

￥ 2,960

5日内发货

500 μg

￥ 15,800

5日内发货

1 mg

￥ 23,700

5日内发货

产品描述

种属	SARS-CoV-2
表达系统	E. coli
标签	C-6His
蛋白编号	YP_009725297.1
别名	SARS-CoV 2 nsp1, SARS-CoV 2 Leader protein
氨基酸序列	Met1-Gly180
蛋白构建	Recombinant 2019-nCoV NSP1 is produced by our E.coli expression system and the target gene encoding Met1-Gly180 is expressed with a 6His tag at the C-terminus.
蛋白纯度	Greater than 85% as determined by reducing SDS-PAGE. (QC verified)
分子量	25 KDa, reducing conditions

缓冲液	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
存储	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输方式	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
研究背景	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.

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SARS-CoV-2 NSP1 Protein (His)

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