目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T16028 | BCL Antibacterial | ||
IMB-XH1 (Mcl1-IN-2) 是一种骨髓细胞因子 1 抑制剂。它也是非竞争性的 Delhi metallo-β-lactamase(NDM-1) 抑制剂。它对金属 β-内酰胺酶 NDM-1,IMP-4,ImiS 和 L1 的 IC50值分别为 0.4637 μM,3.980 μM,0.2287 μM 和 1.158 μM。 | |||
T1882 | Apoptosis | ||
Meisoindigo (Natura-α) 是 Indirubin 的衍生物,可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞,并诱导凋亡,具有高抗肿瘤活性。 | |||
T3184 | Mdm2 p53 | ||
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子,是肿瘤抑制蛋白 p53 的激活剂,具有潜在的抗肿瘤活性。 | |||
T0942 | Apoptosis Mitophagy DNA Phospholipase Parasite Autophagy Histamine Receptor | ||
Quinacrine dihydrochloride (Mepacrine dihydrochloride) 是一种具有口服活性的抗疟剂,抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡,具有抗肿瘤和抗寄生虫活性。 | |||
T2066 | Apoptosis FLT Autophagy Ligands for Target Protein for PROTAC | ||
Quizartinib (AC220) 是一种第二代 Ⅱ 型 FLT3 酪氨酸激酶抑制剂,具有口服活性和高选择性,抑制 FLT3-WT 和 FLT3-ITD 自磷酸化 (IC50=4.1/1.1 nM)。Quizartinib 可以诱导肿瘤细胞凋亡。 | |||
T2346L | Dehydrogenase | ||
Enasidenib mesylate (AG-221 mesylate) 是一种具有有效性和选择性的 IDH2 突变酶抑制剂,可促进白血病成髓细胞的分化,可用于治疗急性髓系白血病。 | |||
T25006 | Dehydrogenase | ||
AGI-14100 是一种新型且可口服的 mIDH1 抑制剂。AGI-14100 用于治疗原发性人类髓性白血病。 | |||
T12629L | BCL | ||
MIK665 (S-64315) (S-64315) 对髓系细胞白血病具有抑制作用。 | |||
T12041 | BCL | ||
MIM1 (Inhibitor of Mcl-1) 是一种骨髓细胞因子 1 抑制剂。 | |||
T4231 | TLR | ||
MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 为 189 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-01774 | TREM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TREM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is Q38L15.
|
|||||
TMPY-01703 | TREM-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TREM-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q99NH8-1.
|
|||||
TMPY-01148 | TREM-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TREM-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.9 kDa and the accession number is Q5TCX1.
|
|||||
TMPY-00432 | TREM-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TREM-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q99NH8-1.
|
|||||
TMPY-01648 | TREML2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 is specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There may be a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation.
|
|||||
TMPY-06527 | TREM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TREM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.57 kDa and the accession number is Q9JKE2-1.
|
|||||
TMPH-01723 | MYD88 Protein, Human, Recombinant (His) | Human | E. coli | ||
MYD88 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q99836.
|
|||||
TMPY-00943 | TREM-1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
TREM-1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 48.3 kDa and the accession number is Q38L15.
|
|||||
TMPH-03100 | PMAP-23 Protein, Pig, Recombinant (His & SUMO) | Sus scrofa (Pig) | E. coli | ||
Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PMAP-23 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P49930.
|
|||||
TMPY-06598 | TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.69 kDa and the accession number is NP_061838.1.
|
|||||
TMPY-04264 | SF20 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
SF20 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q969H8.
|
|||||
TMPY-00034 | SF20 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SF20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q969H8.
|
|||||
TMPY-06566 | TREM-2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TREM-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.16 kDa and the accession number is NP_061838.1.
|
|||||
TMPJ-00115 | TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells | ||
TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is Q9NZC2.
|
|||||
TMPH-00230 | Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli | ||
Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 16.2 kDa and the accession number is P54228.
|
|||||
TMPJ-00117 | TREM-2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
TREM-2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9NZC2.
|
|||||
TMPH-01526 | KMT2E Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.; Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
|
|||||
TMPJ-00537 | Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells | ||
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.
|
|||||
TMPH-01106 | CD300LB Protein, Human, Recombinant (His) | Human | E. coli | ||
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is A8K4G0.
|
|||||
TMPJ-00589 | TREML2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TREML2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 80-110 KDa and the accession number is AAI25079.1.
|
|||||
TMPJ-00193 | TREML1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
|
|||||
TMPH-01947 | PPP1R15A Protein, Human, Recombinant (His) | Human | E. coli | ||
PPP1R15A Protein, Human, Recombinant (His) is expressed in E. coli.
|
|||||
TMPJ-01144 | TREML2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TREML2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 58-62 KDa and the accession number is Q2LA85.
|
|||||
TMPJ-01193 | CLM-9 Protein, Human, Recombinant (aa 19-247, His) | Human | HEK293 Cells | ||
CMRF35-Like Molecule 9 (CD300LG) is a single-pass type I membrane protein which belongs to the CD300 family. CD300LG has one Ig-like V-type domain which mediates binding to lymphocyte. CD300LG is highly expressed in heart, skeletal muscle and placenta. CD300LG acts as a receptor which may mediate L-selectin-dependent lymphocyte rollings. CD300LG also binds SELL in a calcium dependent manner and lymphocyte. CD300LG may play a important role in molecular traffic across the capillary endothelium.
|
|||||
TMPH-03358 | S100A9 Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli | ||
S100A9 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.0 kDa and the accession number is P50116.
|
|||||
TMPY-01840 | TLT-1/TREML1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
|
|||||
TMPH-03366 | RUNX1 Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus Insect Cells | ||
RUNX1 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.4 kDa and the accession number is Q63046.
|
|||||
TMPJ-00014 | Resistin Protein, Human, Recombinant (His) | Human | E. coli | ||
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause "high levels of 'bad' cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes.
|
|||||
TMPJ-00700 | GADD45B Protein, Human, Recombinant (His) | Human | E. coli | ||
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It may serve as a possible therapeutic target.
|
|||||
TMPJ-01470 | SCF Protein, Human, Recombinant | Human | E. coli | ||
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
|
|||||
TMPJ-00042 | TSLP Protein, Human, Recombinant | Human | E. coli | ||
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa, skin and in salivary glands. In aa sequence level, Human TSLP displays about 43% identity with mouse TSLP.TSLP is a cytokine that functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells.TSLP has proliferative effects on the myeloid cell line and may initiate asthma or atopic dermatitis responses by directly activating mast cells . TSLP signals cells via the interleukin-7 receptor-α chain (IL-7Rα),shared with IL-7, together with the TSLP receptor (TSLPR) subunit. Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis,for increased intraarticular TSLP concentrations in patients has caused chemotaxis and activation of arthritogenic T cells.
|
|||||
TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
|
|||||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
|
|||||
TMPK-00620 | TLT-1/TREML1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Triggering receptor expressed on myeloid cells (TREM)-like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a membrane protein receptor found in alpha-granules of platelets and megakaryocytes.
|
|||||
TMPK-01097 | AFP Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.71 kDa and the accession number is Q8MJU5.
|
|||||
TMPK-00488 | AFP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.53 kDa and the accession number is A0A2K5U7U0.
|
|||||
TMPH-02740 | IL-31R alpha Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 59.2 kDa and the accession number is Q8K5B1.
|
|||||
TMPJ-00189 | TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
|
|||||
TMPH-01818 | CD200 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. CD200 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.4 kDa and the accession number is P41217.
|
|||||
TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
|
|||||
TMPK-01033 | PSGL-1/CD162 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.74 kDa and the accession number is Q62170.
|
|||||
TMPK-01267 | TREM-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear.
|
|||||
TMPK-00624 | CD200R1/CRTR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. CD200R1/CRTR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.7 kDa and the accession number is AAQ19772.
|
|||||
TMPK-00128 | CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled | Human | HEK293 Cells | ||
CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 19.3 kDa and the accession number is P09564.
|
|||||
TMPJ-00803 | CD32B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.
|
|||||
TMPK-01238 | PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli | ||
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 76.6 kDa and the accession number is Q9UM07.
|
|||||
TMPK-01364 | SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is P78324 variant 6.
|
|||||
TMPK-01358 | SIRP alpha V6 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is P78324 variant 6.
|
|||||
TMPY-04421 | FES Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. The nuclear localization is confirmed by immunocytochemistry of neutrophils. FES has been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. FES is also involved in normal hematopoiesis. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia.
|
|||||
TMPJ-01237 | IL-17D Protein, Human, Recombinant | Human | E. coli | ||
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays.
|