目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T34940 | |||
Triethylene glycol monoadipate is a biochemical. | |||
T18614 | Others PROTAC Linker | ||
Bis-Tos-PEG4 (PROTAC Linker 16) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T34161 | |||
Propylene glycol monocaprate is a biochemical. | |||
T16665 | Others | ||
Triethylene glycol (PROTAC Linker 25) is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1]. | |||
T17055 | Others | ||
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T20378 | |||
Myristyl glycol is a typical compound of glycol. | |||
T20385 | |||
Divinyl glycol is an agent of biochemical. | |||
T16662 | Others | ||
Tetraethylene glycol (PROTAC Linker 18) is a polyethylene glycol (PEG)-based linker that finds utility in the synthesis of PROTACs[1]. | |||
T31449 | |||
Diethylene glycol monobenzoate is used as a plasticizer. | |||
T21141 | |||
Decylene glycol is used as an antimicrobial agent in cosmetics. It also suppresses the fluidity of the hydrophobic and hydrophilic groups in the phospholipid membrane of liposomes. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-02798 | NEIL1 Protein, Human, Recombinant (His) | Human | E. coli | ||
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision repair of DNA damaged by oxidation or by mutagenic agents. It acts as a DNA glycosylase that recognizes and removes damaged bases. NEIL1 prefers to oxidized pyrimidines, such as thymine glycol, Formamidopyrimidine (Fapy), and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand and cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
|