目录号 | 产品详情 | 靶点 | |
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T22726 | Others | ||
Dioctanoylglycol (ethane-1,2-diyl dioctanoate) 是二酰基甘油类似物,也是二酰基甘油激酶 (DGK) 抑制剂,其Ki=为58 μM。 | |||
T31438 | |||
Didecanoyltriethylene glycol ester is a biochemical. | |||
T18143 | Others PROTAC Linker | ||
m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) 是一种基于 PEG 的 PROTAC 接头,可用于 PROTAC 的合成。它也是一种不可切割的 12 单元 PEG ADC 接头,用于合成抗体-药物偶联物。 | |||
T21019 | |||
Diethylene glycol 与水、酒精、乙醚和乙二醇混溶,是一种广泛使用的溶剂。 | |||
T65456 | |||
Tetraethylene glycol monooctyl ether 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65456,CAS号为 19327-39-0。 | |||
T18214 | Others PROTAC Linker | ||
m-PEG7-alcohol (O-Methyl-heptaethylene glycol) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T40606 | |||
Tetraethylene glycol monohexadecyl ether, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs. | |||
T35879 | |||
Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, intended for stabilizing membrane proteins [1]. | |||
T16337 | Others | ||
Nonaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T13709 | Others | ||
Glycol salicylate is a derivative of salicylic acid and can be used to improve the aesthetic appearance of the skin. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02798 | NEIL1 Protein, Human, Recombinant (His) | Human | E. coli | ||
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision repair of DNA damaged by oxidation or by mutagenic agents. It acts as a DNA glycosylase that recognizes and removes damaged bases. NEIL1 prefers to oxidized pyrimidines, such as thymine glycol, Formamidopyrimidine (Fapy), and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand and cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
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