目录号 | 产品详情 | 靶点 | |
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T79435 | |||
Metallo-β-lactamase-IN-11(化合物5f)是一种针对Metallo-β-lactamases(MBLs)的抑制剂,对CphA表现出较强的抑制活性(IC50=45 µM)。在10 µM浓度下,能分别抑制49%的NDM-1和61%的AIM-1。此化合物对于研究针对抗生素耐药性的策略具有潜在应用价值。 | |||
T60494 | |||
Metallo-β-lactamase-IN-7 是VIM 型金属 β-内酰胺酶的有效抑制剂,其对VIM-2、VIM-1和VIM-5 的IC50值分别为 0.019 μM、13.64 μM 和 0.38 μM。它还可以增强 Meropenem 对革兰氏阴性菌的抗菌活性。 | |||
T72261 | |||
Metallo-β-lactamase-IN-9 (Compound 23) 是一种高效的泛金属-β-内酰胺酶 (MBL) 抑制剂,其对 NDM-1、VIM-1 和 IMP-1 的抑制活性表现在 IC50 值上,分别为 35 nM、269 nM 和 369 nM。 | |||
T5570 | Antibacterial Antibiotic | ||
Cephalothin 是一种 β-内酰胺抗生素,抑制 C 类 β-内酰胺酶活性的 Ki 值为 0.32 µM。 | |||
T14081 | Antibacterial | ||
Enmetazobactam (AAI101) 是一种广谱β-lactamase 抑制剂,有抗耐药革兰氏阴性细菌。 | |||
T60454 | Others | ||
NDM-1 inhibitor-3 是一种广泛存在于自然界中的 New Delhi Metallo-β-lactamase-1 (NDM-1) 抑制剂(Ki : 4 μM),与抗生素耐药有关。 | |||
T17210L1 | Antibacterial | ||
(3R,6R)-Vaborbactam ((3R,6R)-Vaborbactam (Iso-1360457-46-0)) 是一种环状硼酸药效团 β-内酰胺酶 (β-lactamase) 抑制剂,具有潜在的抗菌活性。 | |||
T6685 | Antibacterial Antibiotic | ||
Sulbactam sodium (CP-45899-2) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂。它具有抗菌活性,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。 | |||
T17210 | Antibacterial | ||
Vaborbactam (RPX7009)是一种 β-内酰胺酶抑制剂,常与美罗培南共同作用来研究肺炎和 CRE 感染。 | |||
T1312 | Antibacterial Antibiotic | ||
Nafcillin sodium monohydrate (CL 8491) 是一种抗生素,是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-01157 | LACTB2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is expressed at high levels and annotates structural defects or features in 4 cDNA clones. LACTB2 proteins are expected to have hydrolase activity and metal ion-binding functions. LACTB2 protein is found to localize in mitochondrion. Other functions of LACTB2 is yet unknown.
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TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli with N-terminal 6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa. Accession number: P24735
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TMPH-00588 | Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | Yeast | ||
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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TMPH-03474 | Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant | Salmonella typhimurium | E. coli | ||
Has cefotaxime-hydrolyzing activity.
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TMPH-00584 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli | ||
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
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TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli | ||
Hydrolyzes both carbenicillin and oxacillin.
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TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | Yeast | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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