目录号 | 产品详情 | 靶点 | |
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T9621 | Others | ||
N-(6-chloro-5-(2-Methoxyphenoxy)-2-(pyridin-4-yl)pyriMidin-4-yl)-5-Met 抑制内皮素与CHO 细胞膜上人ETA 受体和人ETB 受体的的结合,IC50分别为268nM 和 1810nM。 | |||
T4435 | Integrin | ||
E7820 (ER68203-00) 是具有口服活性芳香族磺酰胺衍生物,是一种血管生成抑制剂,可抑制内皮上整合素 α2 亚基的表达。它调节 α1,α2,α3 和 α5 整联素 mRNA 表达,具有抗血管生成和抗肿瘤活性。它抑制大鼠主动脉血管生成,IC50为 0.11 μg/ml。 | |||
T1177 | Others Antibacterial Antibiotic Parasite | ||
Sulfaquinoxaline (Sulfabenzpyrazine) 是一种兽用抗菌剂,对革兰氏阴性菌和革兰氏阳性菌均有活性。它能用于预防球虫病和细菌感染。 | |||
T9734 | CDK | ||
InhA-IN-2直接抑制 InhA,不需要过氧化氢酶过氧化物酶 KatG 的激活。 | |||
T0699 | Antibacterial Antibiotic | ||
Sulfamonomethoxine 是一种磺胺类抗菌剂。它可研究血液动力学,竞争性抑制剂二氢叶酸合成,从而阻断叶酸合成。 | |||
T37340 | Others | ||
N4-Acetylsulfamethoxazole 是磺胺甲恶唑的一种代谢物。Sulfamethoxazole 属于磺胺类抗菌素,可用于细菌感染。 | |||
T6992 | Others Antibacterial Antibiotic Parasite | ||
Sulfadiazine sodium (Sulfadiazin-natrium) 是一种磺胺类抗生素具有抗疟活性,可研究弓形虫病。 | |||
T8869 | Others | ||
B355252 是苯氧基噻吩磺酰胺小分子,NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。 | |||
T0917 | Antibacterial Antibiotic Parasite | ||
Sulfaquinoxaline sodium salt (SQ-Na) 是一种兽用广谱抗菌剂,有抗革兰氏阴性菌和革兰氏阳性菌活性。Sulfaquinoxaline 能用于预防球虫病和细菌感染。 | |||
T21435 | Antibacterial | ||
Sulfamoxole (Sulfamoxol) 是一种广谱化疗抗菌剂,可用于小儿感染的相关研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00731 | Carbonic Anhydrase 1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonamide derivatives and coumarins. In addition, CA1 is a zinc metalloenzyme that has reversible hydration of carbon dioxide. It can hydrate cyanamide to urea.
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TMPY-01877 | CA5A Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).
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TMPY-02133 | Carbonic Anhydrase VB Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
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TMPY-01761 | Carbonic Anhydrase 3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion, they are therefore classified as metalloenzymes. Several forms of carbonic anhydrase occur in nature. The primary function of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. Plants contain a different form called β-carbonic anhydrase, which, from an evolutionary standpoint, is a distinct enzyme, but participates in the same reaction and also uses a zinc ion in its active site. Carbonic anhydrase 3, also known as Carbonate dehydratase III, CA-III and CA3, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. CA3 is activated by proton donors such as imidazole and the dipeptide histidylhistidine. It is inhibited by coumarins and sulfonamide derivatives such as acetazolamide. At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.
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