目录号 | 产品详情 | 靶点 | |
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T36914 | Others | ||
2-Hydroxyanthraquinone 是一种天然产物,显示出抗肿瘤和免疫抑制活性。 | |||
T20358 | Antioxidant | ||
Hydroquinone diacetate (NSC-9277) 是一种 OH• 抑制剂,IC50 为 7.59 μM。 | |||
TMO2787 | Virus Protease | ||
Anthraquinone (Anthradione) 是常用于缓解便秘的草药中的主要活性成分,可用作染料形成前体。 | |||
T8352 | Antibacterial | ||
Phanquinone 对广泛的革兰氏阳性和革兰氏阴性生物具有活性。 | |||
T7075 | Others | ||
2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) 是一种取代的萘醌,用作杀虫剂和杀螨剂。 | |||
TN2261 | Others | ||
Tectoquinone 具有很强的杀蚊幼虫活性。 | |||
TN1521 | Antifection Antifungal | ||
Colutehydroquinone 是一种从Colutea arborescens 的根皮中提取的异黄酮,具有抗真菌活性。 | |||
T7106 | Others Endogenous Metabolite | ||
Menaquinone-4 (Vitamin K2) 是维生素 K 的一种,用作止血剂,有潜力用于骨质疏松的研究。 | |||
T12001 | Others | ||
Menaquinone-7 (Vitamin K2(35)) 是一种最早作为抗出血因子被发现的维生素K2家族成员。它是Gla-蛋白羧化反应中最具生物活性的辅因子,补充它也是激活Gla 基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。 | |||
T0223 | Apoptosis Antioxidant Reactive Oxygen Species | ||
Tetrahydroxyquinone (Tetroquinone) 是一种苯醌,是一种抗白内障剂,具有氧化还原活性。它可与半醌自由基一起参与氧化还原循环,导致活性氧形成。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03407 | NQO1 Protein, Human, Recombinant (His) | Human | E. coli | ||
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests the feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.
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TMPH-01225 | DHODH Protein, Human, Recombinant (His) | Human | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-02850 | DHODH Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-02627 | DHODH Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-03278 | DHODH Protein, Rat, Recombinant (His) | Rat | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-00098 | AtAER Protein, Arabidopsis thaliana, Recombinant | Arabidopsis thaliana | E. coli | ||
Involved in the detoxification of reactive carbonyls. Acts on lipid peroxide-derived reactive aldehydes. Specific to a double bond activated by an adjacent carbonyl group. Can use both quinones and diamide as substrates, but not menadione, ferricyanide or phylloquinone. Can use 4-hydroxy-(2E)-nonenal (HNE), 4-hydroxy-(2E)-hexenal (HHE), (2E)-nonenal, (2E)-hexenal, (2E)-pentenal, propenal (acrolein), 3-buten-2-one and 3-penten-2-one, but not (R)-(-)-carvone, n-nonanal, n-hexanal, (3Z)-hexanal, cyclohex-2-en-1-one or 12-oxo phytodienoic acid (OPDA) as electron acceptors. Catalyzes the reduction of the alpha,beta-unsaturated bond of 2-alkenals, of lipid peroxide-derived oxenes 9-oxo-10(E),12(Z)-octadecadienoic acid (9-KODE) and 13-oxo-9(Z),11(E)-octadecadienoic acid (13-KODE), as well as 4-oxo-(2E)-nonenal and 4-hydroxynonenal. Can use 12-oxo-10(E) dodecanoate (traumatin), trans-1,3 diphenyl-2-propenone, trans-1,4-diphenyl-2-butene-1,4-dione, 9-oxo-12,13-epoxy-(10E)-octadecenoic acid (trans-EKODE-1b) and 9,13-dihydroxy-10-oxo-11-octadecenoic acid as substrates. Catalyzes the reduction of the 7-8 double bond of phenylpropanal substrates, such as p-coumaryl aldehyde and coniferyl aldehyde (in vitro). Has activity towards toxic substrates, such as 4-hydroxy-(2E)-nonenal (in vitro). May play a distinct role in plant antioxidant defense and is possibly involved in NAD(P)/NAD(P)H homeostasis.
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TMPH-00097 | AtAER Protein, Arabidopsis thaliana, Recombinant (His & SUMO) | Arabidopsis thaliana | E. coli | ||
Involved in the detoxification of reactive carbonyls. Acts on lipid peroxide-derived reactive aldehydes. Specific to a double bond activated by an adjacent carbonyl group. Can use both quinones and diamide as substrates, but not menadione, ferricyanide or phylloquinone. Can use 4-hydroxy-(2E)-nonenal (HNE), 4-hydroxy-(2E)-hexenal (HHE), (2E)-nonenal, (2E)-hexenal, (2E)-pentenal, propenal (acrolein), 3-buten-2-one and 3-penten-2-one, but not (R)-(-)-carvone, n-nonanal, n-hexanal, (3Z)-hexanal, cyclohex-2-en-1-one or 12-oxo phytodienoic acid (OPDA) as electron acceptors. Catalyzes the reduction of the alpha,beta-unsaturated bond of 2-alkenals, of lipid peroxide-derived oxenes 9-oxo-10(E),12(Z)-octadecadienoic acid (9-KODE) and 13-oxo-9(Z),11(E)-octadecadienoic acid (13-KODE), as well as 4-oxo-(2E)-nonenal and 4-hydroxynonenal. Can use 12-oxo-10(E) dodecanoate (traumatin), trans-1,3 diphenyl-2-propenone, trans-1,4-diphenyl-2-butene-1,4-dione, 9-oxo-12,13-epoxy-(10E)-octadecenoic acid (trans-EKODE-1b) and 9,13-dihydroxy-10-oxo-11-octadecenoic acid as substrates. Catalyzes the reduction of the 7-8 double bond of phenylpropanal substrates, such as p-coumaryl aldehyde and coniferyl aldehyde (in vitro). Has activity towards toxic substrates, such as 4-hydroxy-(2E)-nonenal (in vitro). May play a distinct role in plant antioxidant defense and is possibly involved in NAD(P)/NAD(P)H homeostasis.
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TMPH-02269 | Tyrosinase/TYR Protein, Human, Recombinant (His) | Human | Yeast | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02270 | Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02882 | NQO2 Protein, Mouse, Recombinant (His) | Mouse | Yeast | ||
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
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