Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Menaquinone-4 (Vitamin K2) 是维生素 K 的一种,用作止血剂,有潜力用于骨质疏松的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 415 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 466 | 现货 |
产品描述 | Menaquinone-4 (Vitamin K2) is a vitamin K compound used as a hemostatic agent, and also as adjunctive therapy for the pain of osteoporosis. |
体内活性 | Vitamin K 补充逆转了高脂饮食引起的骨质退化,通过调节成骨细胞和破骨细胞的活性,并在高脂饮食诱导的肥胖小鼠中防止骨质流失[1]。 |
动物实验 | Forty-two male, 4-week-old C57BL/6J mice.?an automated constant-temperature humidity system was used to maintain a temperature of 23°C ± 2°C and humidity of 60% ± 3% for the animals.?The animals were provided with feed and drink ad libitum.?For environmental adaptation, the animals had 1 week of circulation, and then were provided with the experimental diet after being randomly divided into 6 groups (7 animals in each group;?randomized block design).?The AIN-93G diets consisted of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + vitamin K2 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + vitamin K2 (HF-K2).?The vitamin K1 and vitamin K2 contents were 200 mg/1,000 g, and the diet was provided in pellet form.?Food intake amount was measured every other day.?Body weight was measured once a week, and the food efficiency ratio (FER) was calculated by dividing the increased body weight from day1 to the final day by the food intake amount during the experiment period.?For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat were extracted from dead animal subjects, were washed with 0.9% NaCl, dried by filter paper, and then were weighed[1]. |
别名 | 四烯甲萘醌, Vitamin K2, Menaquinone K4 |
分子量 | 444.65 |
分子式 | C31H40O2 |
CAS No. | 863-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.45 mg/mL (10 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.249 mL | 11.2448 mL | 22.4896 mL | 56.224 mL |
5 mM | 0.4498 mL | 2.249 mL | 4.4979 mL | 11.2448 mL | |
10 mM | 0.2249 mL | 1.1245 mL | 2.249 mL | 5.6224 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Menaquinone-4 863-61-6 Metabolism Others Endogenous Metabolite Menaquinone 4 Vitamin K2(MK-4) inhibit Inhibitor Menaquinone K-4 四烯甲萘醌 Vitamin K2 Menaquinone K 4 Menaquinone4 Menaquinone K4 inhibitor