目录号 | 产品详情 | 靶点 | |
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T2S2150 | Others | ||
Noricaritin 是一种来源于淫羊藿根的黄酮类化合物。 | |||
TN7128 | Others | ||
4,6,3',4'-Tetrahydroxyaurone 是一种来自 Heleocharis dulcis 草本的类黄酮。 | |||
TN1489 | Others | ||
3'-Methoxyapiin (Graveobioside B) 是一种来自 Eminium spiculatum 植物的类黄酮。 | |||
T2O2770 | Others | ||
Agarotetrol 是一种色酮衍生物,从沉香中分离得到。 | |||
T13761 | Others | ||
Luteolin 7-diglucuronide 是一种从马鞭草 Verbena officinalis 和三叶草 Aloysia triphylla 中提取的类黄酮。 | |||
T0723 | Potassium Channel 5-HT Receptor | ||
Cloperastine hydrochloride (HT-11 hydrochloride) 是 hERG K+电流的抑制剂,IC50为 27 nM,具有浓度依赖性。 | |||
TN3689 | Others | ||
Comanthoside A (Comanthosid A) 是一种可从 Comanthosphace japonica 中分离的天然黄酮苷。Comanthoside A 也 是合成 Linaroside和 Comanthoside B 的关键中间体。 | |||
TN3120 | Histone Demethylase Antiviral | ||
5-Hydroxy-7-acetoxy-8-methoxyflavone 是一种类黄酮化合物,可以抑制脂质过氧化,可能具有抗流感病毒活性。 | |||
T5S2139 | Others | ||
Epimedin A1 (Hexandraside F) 是一种黄酮类化合物,从常用中药淫羊藿中提取得到。 | |||
T0228 | Akt PKC | ||
Methyl hesperidin 是一种血管扩张剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01579 | GBA3 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
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TMPY-02041 | Cortisol Binding Globulin Protein, Human, Recombinant (His) | Human | HEK293 | ||
Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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TMPY-06702 | Cortisol Binding Globulin Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 | ||
Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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TMPY-05099 | GBA/glucocerebrosidase Protein, Human, Recombinant (His) | Human | HEK293 | ||
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD.
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TMPY-02107 | Cortisol Binding Globulin Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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TMPY-05329 | Cortisol Binding Globulin Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 | ||
Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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TMPY-00027 | GSTT2B Protein, Human, Recombinant (His) | Human | HEK293 | ||
GSTT2B Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 29 kDa. Accession number: P0CG29
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