目录号 | 产品详情 | 靶点 | |
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T60336 | CCR | ||
CCR4 antagonist 3-1 是一种具有较低活性的趋化因子受体 4 (CCR4) 拮抗剂,对 [125I]TARC (胸腺和活化调节趋化因子) 具有抑制作用,IC50 值为 1.7 μM。CCR4 antagonist 3-1 对放射标记的[125I]TARC和巨噬细胞来源的趋化因子(MDC) 与 CEM 细胞表面的CCR4 受体的结合有抑制作用, 并对 TARC 介导的 CEM 细胞的体外迁移有抑制作用,IC50 值为 6.4 μM。 | |||
T24700 | CCR | ||
R243 是选择性的CCR8拮抗剂,可抑制CCL1/CCR8的相互作用,以及CCR8信号传导和趋化性,具有抗伤害感受和抗炎作用。 | |||
T6413 | CCR | ||
Bindarit (AF2838) 是单核细胞趋化蛋白MCP-1/CCL2,MCP-3/CCL7和MCP-2/CCL8的选择性抑制剂,具有抗炎作用。 | |||
T11699 | CCR | ||
J-113863 是选择性的 CCR1 (CD18)拮抗剂,有抗炎作用,对人和小鼠 CCR1受体的 IC50值分别为 0.9 和 5.8 nM。它是人 CCR3的强效拮抗剂,还是小鼠 CCR3的弱效拮抗剂,IC50分别为 0.58 和 460 nM。 | |||
T16111 | CCR | ||
ML604086 是选择性CCR8抑制剂,抑制循环T 细胞上 CCL1 与 CCR8 结合,还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。 | |||
T77349 | Phospholipase | ||
CCR1/5/8 activator 1 是胞质磷脂酶 A 抑制剂,具有抗真菌活性。 | |||
T10425 | CCR | ||
AZ084 是可口服的选择性 CCR8变构拮抗剂,其Ki 值为 0.9 nM,可研究哮喘。 | |||
T16091 | Others CCR | ||
MK-0812 Succinate 是一种选择性CCR2拮抗剂。 | |||
T4584 | CCR | ||
BMS-813160 是CCR2/CCR5双重拮抗剂。有用于心血管的研究潜力。 | |||
T12773 | Others 5-HT Receptor CCR | ||
RS102895 hydrochloride 是一种CCR2拮抗剂,IC50值为 360 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPK-00879 | CCR2b Protein-VLP, Human, Recombinant | Human | HEK293 | ||
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.
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TMPK-00897 | CCR8 Protein, Human, Recombinant (mFc) | Human | HEK293 | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
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TMPK-00896 | CCR8 Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
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TMPK-01316 | CCR8 Protein, Cynomolgus, Recombinant (mFc) | Cynomolgus | HEK293 | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
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TMPH-01065 | CCR4 Protein-VLP, Human, Recombinant (His) | Human | HEK293 | ||
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
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TMPH-01064 | CCR4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
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TMPH-01066 | CCR6 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20.
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TMPK-00008 | CCL5 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 | ||
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers.
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TMPK-00009 | CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | E. coli | ||
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers.
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