目录号 | 产品详情 | 靶点 | |
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T80087 | Neuropeptide Y Receptor | ||
'(Leu31,Pro34)-Peptide YY (human)(TFA)' 为 '(Leu31,Pro34)-Peptide YY (human)' 的 TFA 盐形式,该化合物为 Peptide YY 的衍生物,兼具高效和选择性的 Y1 受体激动剂特性,其 KD 值为 1.0 nM。 | |||
T60338 | |||
Antibacterial agent 117是一种三唑衍生物,可作为抗菌剂。Antibacterial agent 117 具有抗 R. prowazekiiMetAP1 (RpMetAP1)活性,其 IC50值为 15 μM。Antibacterial agent 117 也可抑制立克次体生长,可用于感染的研究。 | |||
T78510 | Others | ||
Zolimidine是一种咪唑并吡啶衍生物,可作为口服抗溃疡剂。它能刺激肠粘膜细胞分泌粘液,增强肠壁的抗溃疡能力,并在十二指肠溃疡研究中显示出胃保护效果。 | |||
T74513 | |||
RPR103611,一个桦木酸衍生物,作为HIV-1入侵抑制剂表现出高效性,其对CCR5(热带)病毒YU2、CXCR4(热带)病毒NL4-3及双热带病毒89.6的IC50分别达到80、0.27和0.17。 | |||
T63409 | |||
Teclozan 是一种苄胺衍生物类的抗原虫剂。Teclozan 在肠腔中表现出抗 G. intestinalis 作用,能够干预磷脂代谢,阻止花生四烯酸的形成。Teclozan 能够用于研究原生动物感染。 | |||
T64180 | |||
GLP-1R agonist 1 是一种增稠的咪唑衍生物化合物,也是一种 GLP-1R 的有效激动剂。其中胰高血糖素样肽-1 (GLP-1) 是一种肠道降血糖激素,分泌自下消化道 L 细胞。GLP-1R agonist 1 具有研究糖尿病的潜力。 | |||
T35556 | GSK-3 Wnt/beta-catenin | ||
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。 | |||
T78940 | Apoptosis | ||
EGFR-IN-78(compound A5)为2-氨基嘧啶衍生物,既是EGFRC797S-TK的可逆抑制剂,也能诱导细胞凋亡(apoptosis)。该化合物展现抗增殖能力,阻止EGFR磷酸化,导致细胞周期在G2/M期暂停。 | |||
T72605 | |||
C-RAFkinase-IN-1 是一种有效的C-RAF 激酶抑制剂,IC50为 0.193 μM。C-RAFkinase-IN-1 是一种喹啉衍生物。C-RAFkinase-IN-1 具有研究癌症疾病的潜力。 | |||
T78068 | Others | ||
O-allylvanillin为o-烯丙基查尔酮衍生物,呈现抗癌活性。该化合物对THP-1、HL60、Hep-G2、MCF-7细胞系生长抑制作用显著,其IC50值依次为74.76 μM、63.52 μM、90.99 μM、90.11 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00295 | PAG-2 Protein, Bovine, Recombinant (His) | Bovine | E. coli | ||
PAG2 or a processed derivative of this molecule might represent a factor that binds the LH receptor.
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TMPH-02461 | pylS Protein, Methanosarcina barkeri, Recombinant (His) | Methanosarcina barkeri | E. coli | ||
Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
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TMPH-02564 | CARNMT1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
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TMPH-01525 | CMAHP Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates. However, it may play a role in Wnt signaling.
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TMPH-00271 | HNRNPA2B1 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli | ||
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs.
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TMPY-00585 | Annexin A8 Protein, Human, Recombinant (His) | Human | E. coli | ||
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ductal epithelium, while its expression in basal-like breast cancers may be linked to ANXA8's association with their specific cells of origin. Annexin A8 (ANXA8), a member of a superfamily of calcium and phospholipid binding proteins, is physiologically expressed in a tissue-specific manner, recent microarray studies reported that ANXA8 was also ectopically expressed in pancreatic cancers. We investigated the molecular mechanism of expression of ANXA8 in cancer cells and its functional role in pancreatic cancer cells. ANXA8 was diversely expressed in human cancer cell lines. Ectopic ANXA8 expression in cancer cells might involve an epigenetic mechanism. ANXA8 might play an important role in calcium fluctuation-mediated HIF-1α transcriptional activation and cell viability. The retinoic acid derivative fenretinide (FR) is capable of transdifferentiating cultured retinal pigment epithelial (RPE) cells towards a neuronal-like phenotype, down-regulation of AnxA8 is both necessary and sufficient for neuronal transdifferentiation of RPE cells and reveal an essential role for AnxA8 as a key regulator of RPE phenotype.
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