目录号 | 产品详情 | 靶点 | |
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T13570 | Others | ||
Benzamide Derivative 1 苯甲酰胺衍生物,具有胃动力学活性。Benzamide Derivative 1可用于研究胃肠疾病。 | |||
T13751 | Others | ||
L-Threonine derivative-1 是乙酰水杨酸-L-苏氨酸酯,具有潜在的镇痛活性。 | |||
T11550 | HBV | ||
Helioxanthin derivative 5-4-2 (Helioxanthin 5-4-2) 是螺旋黄质的类似物,在体外显示出抗 HBV 活性,可用于研究HBV。 | |||
T11421 | transporter | ||
Glutaminase-IN-1 (CB839 derivative),是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂,在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。 | |||
T12717 | GluR | ||
Basimglurant (CTEP Derivative) 是一种高效,选择性,可口服的 mGlu5负变构调节剂,Kd 值为1.1 nM。 | |||
T38506 | |||
cis-Clopidogrel-MP derivative, also known as Clopidogrel-MP-AM, is a 3’-methoxyacetophenone derivative of Clopidogrel active metabolite. This compound is an orally-active platelet inhibitor specifically targeting the P2Y12 receptor. | |||
TP1154 | |||
GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative. | |||
T26397 | Dehydrogenase | ||
6PGD-IN-S3 (6PGD Inhibitor S3) 是 6-磷酸葡萄糖酸脱氢酶 (6PGD) 的抑制剂。 | |||
T11249L | Topoisomerase | ||
Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂,IC50值为 0.31 μM,用作HER2靶向ADC 的偶联药物。 | |||
T39320 | |||
Hemiasterlin Derivative-1, a derivative of hemiasterlin, is utilized in the synthesis of Antibody-Drug Conjugates (ADC). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00295 | PAG-2 Protein, Bovine, Recombinant (His) | Bovine | E. coli | ||
PAG2 or a processed derivative of this molecule might represent a factor that binds the LH receptor.
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TMPH-02461 | pylS Protein, Methanosarcina barkeri, Recombinant (His) | Methanosarcina barkeri | E. coli | ||
Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
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TMPH-02564 | CARNMT1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
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TMPH-01525 | CMAHP Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates. However, it may play a role in Wnt signaling.
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TMPH-00271 | HNRNPA2B1 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli | ||
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs.
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TMPY-00585 | Annexin A8 Protein, Human, Recombinant (His) | Human | E. coli | ||
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ductal epithelium, while its expression in basal-like breast cancers may be linked to ANXA8's association with their specific cells of origin. Annexin A8 (ANXA8), a member of a superfamily of calcium and phospholipid binding proteins, is physiologically expressed in a tissue-specific manner, recent microarray studies reported that ANXA8 was also ectopically expressed in pancreatic cancers. We investigated the molecular mechanism of expression of ANXA8 in cancer cells and its functional role in pancreatic cancer cells. ANXA8 was diversely expressed in human cancer cell lines. Ectopic ANXA8 expression in cancer cells might involve an epigenetic mechanism. ANXA8 might play an important role in calcium fluctuation-mediated HIF-1α transcriptional activation and cell viability. The retinoic acid derivative fenretinide (FR) is capable of transdifferentiating cultured retinal pigment epithelial (RPE) cells towards a neuronal-like phenotype, down-regulation of AnxA8 is both necessary and sufficient for neuronal transdifferentiation of RPE cells and reveal an essential role for AnxA8 as a key regulator of RPE phenotype.
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