目录号 | 产品详情 | 靶点 | |
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T37554 | |||
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 μM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulmonary inflammatory reaction followed by chronic neuropathy, myalgia, and autoimmune connective tissue disease, generally referred to as toxic oil syndrome (TOS). Aniline-denatured cooking oil is a source of OA associated with TOS. | |||
T73852 | |||
Ac-YVAD-CHO(L-709049)醋酸盐是一种高效、可逆、特异的四肽白介素1β转化酶(ICE)抑制剂,小鼠和人类的Ki值分别为3.0 nM和0.76 nM。它同时也能抑制caspase-1,从而抑制成熟IL-lβ的产生。 | |||
T36668 | |||
Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also inhibits lysine-specific demethylase 1 (LSD1; IC50= 46.97 μM).3 1.Shidoji, Y., and Ogawa, H.Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbsJ. Lipid Res.45(6)1092-1103(2004) 2.Shidoji, Y., Nakamura, N., Moriwaki, H., et al.Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosisBiochem. Biophys. Res. Commun.230(1)58-63(1997) 3.Sakane, C., Okitsu, T., Wada, A., et al.Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivativesBiochem. Biophys. Res. Commun.444(1)24-29(2014) | |||
T68306 | |||
INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of myeloma xenografts in mice and enhanced the antitumor activity of relevant agents in combination studies. INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents. ( source: Neoplasia. 2010 Jan;12(1):28-38. ). | |||
TP1516 | |||
C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring-shaped) | |||
T37604 | |||
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminomethyl)benzamide) is the analogue of BMS-509744, which can potently and selectively inhibit Itk kinase activity. In vitro: BMS-509744 could reduce TCR-induced functions including PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion, and T-cell proliferation in vitro in both human and mouse cells [1]. In vivo: BMS-509744 suppressed the production of IL-2 induced by anti-TCR antibody administered to mice. BMS-509744 also significantly diminishes lung inflammation in a mouse model of ovalbumin-induced allergy/asthma [1]. Clinical trial: Up to now, both BMS-509744 and ITK inhibitor is still in the preclinical development stage. | |||
T37331 | |||
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM. | |||
T35615 | |||
Dabcyl YVADAPV EDANS 是一种荧光 IL-1β 转化酶 (interleukin-1β converting enzyme, ICE) 底物,可用于检测 ICE 样蛋白酶活性。Dabcyl YVADAPV EDANS 检测荧光的 λex=360 nm,λem=480 nm。 | |||
T81917 | |||
Lorukafusp alfa(14.18 mAb; hu14.18-IL2)是一种由人源化14.18抗GD2抗体和IL210连接而成的免疫细胞因子。该化合物通过其hu14.18-IL2与肿瘤细胞表面的GD2结合,激活抗体依赖性细胞毒性(ADCC)和补体依赖性细胞毒性,以及与效应细胞上Fc受体结合并激活NK和T细胞的活性,从而显现出抗肿瘤效果。 | |||
TN4592 | IL Receptor TNF COX Prostaglandin Receptor | ||
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04717 | CD122/IL2RB Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD122/IL2RB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is H9Z8K1.
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TMPY-02934 | IL-2RG Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-2RG Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q68FU6.
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TMPY-05842 | IL-11 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli | ||
IL-11 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.39 kDa and the accession number is P20808.
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TMPY-05102 | CD122/IL2RB Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD122/IL2RB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P26896.
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TMPY-02568 | IL-1 beta/IL-1F2 Protein, Canine, Recombinant | Canine | E. coli | ||
IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292.
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TMPY-00095 | IL-3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P08700.
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TMPY-05274 | IL-23R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1.
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TMPY-00843 | IL-25/IL17E Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
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TMPY-03951 | IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9.
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TMPY-02824 | IL-18R alpha Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2.
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TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-34 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q8R1R4-1.
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TMPY-05840 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.56 kDa and the accession number is P59822-1.
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TMPY-00635 | IL-7R alpha/CD127 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-7R alpha/CD127 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is Q38IC7.
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TMPY-05090 | CD25/IL2R alpha Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
CD25/IL2R alpha Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is A6JLS0.
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TMPY-05644 | CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated | Rhesus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.9 kDa and the accession number is Q5MNY4.
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TMPY-00418 | IL-21R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-21R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is AAL82636.1.
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TMPY-03776 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.4 kDa and the accession number is H6WS54.
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TMPY-03644 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is H6WS54.
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TMPY-03383 | IL-7 Protein, Human, Recombinant | Human | E. coli | ||
IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.
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TMPY-01738 | IL-1 alpha/IL-1A Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-1 alpha/IL-1A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is P01582.
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TMPY-05492 | IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) | Human | HEK293 Cells | ||
IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1.
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TMPY-02959 | IL-20 Protein, Human, Recombinant | Human | E. coli | ||
IL-20 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NYY1.
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TMPY-01767 | IL-12RB2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-12RB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70 kDa and the accession number is P97378.
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TMPY-00846 | IL-18BP Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.
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TMPY-00855 | IL-25/IL17E Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-25/IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.
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TMPY-05296 | IL-34 Protein, Human, Recombinant (His) | Human | CHO Cells | ||
IL-34 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is AAH29804.1.
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TMPY-01934 | IL-21R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-21R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9HBE5-1.
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TMPY-01845 | IL-10 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P22301.
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TMPY-05480 | IL-21R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-21R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52 kDa and the accession number is Q9HBE5.
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TMPY-01258 | IL-13RA1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
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TMPY-00437 | IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.1 kDa and the accession number is A6IIX5.
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TMPY-01871 | IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) | Human | HEK293 Cells | ||
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
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TMPY-02227 | IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) | Rat | E. coli | ||
IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is Q63264-1.
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TMPY-02445 | IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P48090.
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TMPY-03942 | IL-36 gamma Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
IL-36 gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q8R460.
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TMPY-03298 | IL-6 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
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TMPY-00841 | IL-13RA2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
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TMPY-01170 | IL-13RA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-13RA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is O09030.
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TMPY-00524 | IL-7 Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.
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TMPY-05782 | IL-18R alpha Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098.
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TMPY-01376 | IL-18R alpha Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is Q61098.
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TMPY-03547 | IL-10 Protein, Human, Recombinant | Human | E. coli | ||
IL-10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is P22301.
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TMPY-00297 | IL-3 Protein, Human, Recombinant(aa 20-152) | Human | E. coli | ||
IL-3 Protein, Human, Recombinant(aa 20-152) is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P08700.
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TMPY-02789 | IL-33 Protein, Canine, Recombinant | Canine | E. coli | ||
IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863.
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TMPY-01923 | CD25/IL2R alpha Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD25/IL2R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P01590.
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TMPY-05449 | IL-33 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli | ||
IL-33 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.1 kDa and the accession number is A0A2K5W3I1.
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TMPY-03327 | IL-6 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-6 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QRZ4.
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TMPY-02457 | IL-2 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-2 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is P17108.
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TMPY-00982 | IL-13 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
IL-13 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.3 kDa and the accession number is Q0PW92.
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TMPY-01928 | IL-18 Protein, Rhesus, Recombinant (His) | Rhesus | E. coli | ||
IL-18 Protein, Rhesus, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q9BGI5.
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