目录号 | 产品详情 | 靶点 | |
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T69451 | |||
R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated adjuvant-induced hyperalgesia with rapid onset and long duration comparable to a cyclooxygenase-2 inhibitor, celecoxib. | |||
T78508 | IFNAR | ||
Delmitide acetate (RDP58) 是一种 d-异构体十肽,具有抗炎活性和口服活性。该化合物能够抑制 TNF-α、IFN-γ 以及白细胞介素 (IL)-12 的生成,同时提高血红素加氧酶 1 的活性,可用于针对溃疡性结肠炎的研究。 | |||
T24174 | |||
IRAK4-IN-16 (compound 4) 是一种强效的白细胞介素 -1 受体相关激酶 4(IRAK4) 抑制剂,IC50为 2.5 nM。IRAK4-IN-16 对 OCI-LY10、TMD8、Ramos 和 HT 细胞表现出细胞毒性活性,其 IC50分别为 0.2、0.2、0.6 和 2.7 μM。 | |||
T62950 | |||
IRAK4-IN-18 是一种白介素 1 受体相关激酶 4 (IRAK4) 的有效抑制剂 (IC50: 15 nM)。IRAK4-IN-18 能够抑制 THP 和 DC 细胞中 LPS 诱导的 IL23 产生,阻断关节炎模型大鼠的关节炎发展。IRAK4-IN-18 可用于研究关节炎疾病。 | |||
TN4490 | ERK BCL p38 MAPK TNF NF-κB JNK STAT Antifection | ||
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production. | |||
T72120 | |||
Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸,可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂,可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究,如炎症性贫血 (AI)。 | |||
T63315 | |||
IRAK4-IN-19 是白介素 1 受体相关激酶 4 (IRAK4) 的有效抑制剂 (IC50: 4.3 nM)。IRAK4-IN-19 能够阻碍 THP 和 DC 细胞中 LPS 诱导的 IL23 产生,抑制关节炎模型大鼠的关节炎发展。IRAK4-IN-19 能够用于研究关节炎疾病。 | |||
T76675 | |||
Clazakizumab是一种具有高亲和力和特异性的单克隆抗体,针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外,Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。 | |||
T73697 | |||
Denileukin diftitox (DAB 389IL-2) 是一种融合蛋白毒素,将白喉毒素 (DT) 与白细胞介素 2 (IL-2) 结合,专门针对表达高亲和力IL-2受体 (IL-2R)、CD25 的细胞。它通过与IL-2R阳性细胞结合并利用白喉毒素片段的内化作用来抑制蛋白质合成,从而达到耗尽目标细胞的效果。 | |||
T74843 | |||
ITKdegrader 1 是一种高度选择性的白细胞介素 2 诱导的 T 细胞激酶 (ITK) 降解剂 (DC50=3.6 nM)。ITKdegrader 1 快速、持久地诱导 ITK 降解,并抑制体内抗 CD3抗体刺激的 IL-2分泌 (EC50=35.2 nM,Jurkat 细胞)。ITKdegrader 1 也显示出良好的血浆暴露水平。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04717 | CD122/IL2RB Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD122/IL2RB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is H9Z8K1.
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TMPY-02934 | IL-2RG Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-2RG Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q68FU6.
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TMPY-05842 | IL-11 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli | ||
IL-11 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.39 kDa and the accession number is P20808.
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TMPY-05102 | CD122/IL2RB Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD122/IL2RB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P26896.
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TMPY-02568 | IL-1 beta/IL-1F2 Protein, Canine, Recombinant | Canine | E. coli | ||
IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292.
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TMPY-05274 | IL-23R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1.
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TMPY-00843 | IL-25/IL17E Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
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TMPY-00095 | IL-3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P08700.
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TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-34 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q8R1R4-1.
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TMPY-03951 | IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9.
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TMPY-02824 | IL-18R alpha Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2.
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TMPY-05840 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.56 kDa and the accession number is P59822-1.
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TMPY-00635 | IL-7R alpha/CD127 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-7R alpha/CD127 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is Q38IC7.
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TMPY-05090 | CD25/IL2R alpha Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
CD25/IL2R alpha Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is A6JLS0.
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TMPY-05644 | CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated | Rhesus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.9 kDa and the accession number is Q5MNY4.
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TMPY-00418 | IL-21R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-21R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is AAL82636.1.
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TMPY-03776 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.4 kDa and the accession number is H6WS54.
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TMPY-03644 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is H6WS54.
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TMPY-03383 | IL-7 Protein, Human, Recombinant | Human | E. coli | ||
IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.
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TMPY-01738 | IL-1 alpha/IL-1A Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-1 alpha/IL-1A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is P01582.
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TMPY-05492 | IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) | Human | HEK293 Cells | ||
IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1.
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TMPY-02959 | IL-20 Protein, Human, Recombinant | Human | E. coli | ||
IL-20 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NYY1.
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TMPY-01767 | IL-12RB2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-12RB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70 kDa and the accession number is P97378.
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TMPY-00846 | IL-18BP Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.
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TMPY-00855 | IL-25/IL17E Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-25/IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.
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TMPY-05296 | IL-34 Protein, Human, Recombinant (His) | Human | CHO Cells | ||
IL-34 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is AAH29804.1.
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TMPY-00437 | IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.1 kDa and the accession number is A6IIX5.
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TMPY-01845 | IL-10 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P22301.
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TMPY-05480 | IL-21R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-21R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52 kDa and the accession number is Q9HBE5.
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TMPY-01258 | IL-13RA1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
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TMPY-01934 | IL-21R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-21R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9HBE5-1.
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TMPY-01871 | IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) | Human | HEK293 Cells | ||
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
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TMPY-03942 | IL-36 gamma Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
IL-36 gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q8R460.
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TMPY-03298 | IL-6 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
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TMPY-02227 | IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) | Rat | E. coli | ||
IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is Q63264-1.
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TMPY-02445 | IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P48090.
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TMPY-00841 | IL-13RA2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
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TMPY-00524 | IL-7 Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.
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TMPY-01170 | IL-13RA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-13RA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is O09030.
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TMPY-00297 | IL-3 Protein, Human, Recombinant(aa 20-152) | Human | E. coli | ||
IL-3 Protein, Human, Recombinant(aa 20-152) is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P08700.
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TMPY-03547 | IL-10 Protein, Human, Recombinant | Human | E. coli | ||
IL-10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is P22301.
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TMPY-05782 | IL-18R alpha Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098.
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TMPY-01376 | IL-18R alpha Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is Q61098.
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TMPY-05523 | IL-31 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-31 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.8 kDa and the accession number is A0A8J8XFW3.
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TMPY-05449 | IL-33 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli | ||
IL-33 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.1 kDa and the accession number is A0A2K5W3I1.
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TMPY-03327 | IL-6 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-6 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QRZ4.
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TMPY-02457 | IL-2 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-2 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is P17108.
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TMPY-00982 | IL-13 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
IL-13 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.3 kDa and the accession number is Q0PW92.
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TMPY-01928 | IL-18 Protein, Rhesus, Recombinant (His) | Rhesus | E. coli | ||
IL-18 Protein, Rhesus, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q9BGI5.
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TMPY-02789 | IL-33 Protein, Canine, Recombinant | Canine | E. coli | ||
IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863.
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