目录号 | 产品详情 | 靶点 | |
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TP1910 | |||
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit | |||
T79962 | Others | ||
Aloenin aglycone (compound 13) 作为一种NF-κB抑制剂,可从芦荟渗出液中提取。它在抑制TNFα引发的NF-κB转录活性方面表现显著(IC50: 18.7 μM)。当HepG2细胞经10 ng/mL TNFα处理时,以10 μM Aloenin aglycone处理能有效下调诱导型一氧化氮合酶(iNOS)及细胞间粘附分子1(ICAM-1)的基因表达。 | |||
T70368 | |||
SF0166 是一种有效的选择性 αvβ3拮抗剂,对于 αvβ3,αvβ6,和 αvβ8的IC50值分别为 0.6 nM, 8 nM 和 13 nM。SF0166 抑制人、大鼠、兔和狗细胞系中玻连蛋白的细胞粘附,IC50值为 7.6 pM 至 76 nM。SF0166 在氧诱导视网膜病变小鼠模型中减少新生血管。 | |||
T60439 | |||
CAY10789 (化合物 6) 是有效的CysLT1R 拮抗剂 ,IC50值为2.80 μM。CAY10789 也是一种GPBAR1激动剂 ,EC50为3 μM。CAY10789 显著降低 U937 细胞对 HAEC 的粘附并降低 TNF-α 的表达。CAY10789 表现出有前途的代谢稳定性和出色的药代动力学。 CAY10789 可用于结肠炎、代谢综合征和其他 GPBAR1/CysLT1R 相关疾病的研究。 | |||
T36367 | |||
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 μM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 μM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid. | |||
T82073 | |||
Immune cell migration-IN-2,例11的有效免疫细胞迁移抑制剂,在T细胞粘附试验中显示出13.5 nM的EC50,具有应用于干眼症与视网膜疾病研究的潜力。Immune cell migration-IN-2作为点击化学试剂,含有Alkyne基团,能够与含Azide基团的分子通过铜催化的叠氮-炔环加成反应(CuAAc)进行反应。 | |||
T37631 | |||
12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger's Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound. | |||
T79731 | Necroptosis | ||
MLKL-IN-6(compound P28)是一种针对Mixed Lineage Kinase domain-like(MLKL)的混合谱系激酶抑制剂,具有抗纤维化的潜力。它能够抑制MLKL的磷酸化和寡聚化,从而抑制细胞坏死、免疫细胞死亡,并减少粘附因子的表达。MLKL-IN-6展现出低细胞毒性,并可抑制肝星状细胞的激活,从而降低肝纤维化标志物的水平。 | |||
T35459 | |||
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC50 ≥ 10 μM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM). | |||
T82379 | |||
FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维,并有助于促进肌动蛋白应力纤维的形成,进而介导成纤维细胞附着,显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用,而在 EDTA 存在下,其活性则会被破坏。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03722 | EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is XP_005576740.1.
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TMPY-05017 | ICAM-1/CD54 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is Q5NKV6.
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TMPY-05050 | CEACAM5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.5 kDa and the accession number is XP_005589491.1.
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TMPY-01578 | CD166/ALCAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD166/ALCAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is Q13740-1.
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TMPY-01830 | VCAM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.8 kDa and the accession number is Q3UPN1.
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TMPY-00480 | NCAM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
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TMPY-00981 | ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) | Human | HEK293 Cells | ||
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.2 kDa and the accession number is A0A384MEK5.
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TMPY-01647 | CEACAM5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A0A024R0K5.
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TMPY-01142 | ICAM-1/CD54 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-1/CD54 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51 kDa and the accession number is A0A384MEK5.
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TMPY-01349 | ICAM-1/CD54 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
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TMPY-00947 | VCAM-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
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TMPY-05850 | CEACAM6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1.
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TMPY-00970 | CD31/PECAM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD31/PECAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is EAW94208.1.
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TMPY-00971 | CEACAM6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
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TMPY-04123 | CEACAM1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
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TMPY-01850 | CEACAM3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.
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TMPY-01298 | CADM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CADM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9BY67-1.
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TMPY-01431 | L1CAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1.
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TMPY-02745 | ESAM Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
ESAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is Q6AYD4.
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TMPY-03039 | JAM-B Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
JAM-B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.3 kDa and the accession number is Q3MHC0.
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TMPY-02744 | CADM3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CADM3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q1WIM3.
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TMPY-00534 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant | Cynomolgus,Rhesus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is G7PM59.
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TMPY-03003 | EpCAM/TROP1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
EpCAM/TROP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.8 kDa and the accession number is O55159.
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TMPY-00533 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) | Cynomolgus,Rhesus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is G7PM59.
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TMPY-04039 | CADM3 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CADM3 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.5 kDa and the accession number is Q1WIM3.
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TMPY-03040 | JAM-B Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
JAM-B Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.7 kDa and the accession number is Q3MHC0.
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TMPY-02017 | ICAM-1/CD54 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.7 kDa and the accession number is Q00238-1.
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TMPY-05587 | EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.7 kDa and the accession number is P16422.
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TMPY-00239 | ICAM-1/CD54 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 77.6 kDa and the accession number is A6JNN2.
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TMPY-02939 | EpCAM/TROP1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
EpCAM/TROP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.2 kDa and the accession number is O55159.
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TMPY-03520 | CD166/ALCAM Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD166/ALCAM Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.3 kDa and the accession number is G7NZQ8.
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TMPY-00797 | ESAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q96AP7-1.
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TMPY-00249 | CD166/ALCAM Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
CD166/ALCAM Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.9 kDa and the accession number is F7E9U2.
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TMPY-01300 | EpCAM/TROP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
EpCAM/TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422.
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TMPY-02936 | CD166/ALCAM Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD166/ALCAM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.5 kDa and the accession number is O35112.
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TMPY-03912 | CD166/ALCAM Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CD166/ALCAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is O35112.
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TMPY-03874 | NCAM1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
NCAM1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 79.2 kDa and the accession number is P13596-1.
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TMPY-00798 | ESAM Protein, Human, Recombinant | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is Q96AP7-1.
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TMPY-01312 | ESAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is Q96AP7-1.
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TMPY-00826 | ICAM-2/CD102 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
ICAM-2/CD102 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 50.3 kDa and the accession number is P13598.
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TMPY-01418 | ICAM-2/CD102 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-2/CD102 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P13598.
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TMPJ-00930 | VCAM-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction.
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TMPY-00251 | ICAM-5 Protein, Human, Recombinant (aa 1-570,hFc) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (aa 1-570,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.9 kDa and the accession number is Q9UMF0.
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TMPY-04155 | NCAM2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NCAM2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is O15394-1.
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TMPY-04151 | NCAM2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NCAM2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is O15394-1.
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TMPY-06535 | CEACAM5 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
CEACAM5 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.76 kDa and the accession number is XP_005589491.1.
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TMPY-02734 | ESAM Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ESAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is Q925F2.
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TMPY-00388 | ICAM-5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q9UMF0.
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TMPY-00191 | ICAM-5 Protein, Human, Recombinant (aa 1-132,hFc) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (aa 1-132,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.6 kDa and the accession number is Q9UMF0.
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TMPY-02999 | BCAM Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
BCAM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q9ESS6.
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