目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T36385 | |||
Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B . | |||
T76007 | |||
RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂,阻碍α5β1与细胞外基质(ECM)的结合,并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。 | |||
T36650 | |||
Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A . | |||
T78288 | |||
Inclacumab(Anti-HumanselectinP Recombinant Antibody)是一种人源化IgG4单克隆抗体,专一性靶向P-selectin,Kd为9.9 nM。该抗体能够抑制P-selectin糖蛋白配体1(PSGL-1)模拟肽与P-selectin的结合,其IC50为1.9 µg/mL,且显著抑制细胞粘附。 | |||
T35582 | |||
H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.4 1.Park, H.S., Kim, C., and Kang, Y.K.Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to plateletsBiopolymers63(5)298-313(2002) 2.Tranqui, L., Andrieux, A., Hudry-Clergeon, G., et al.Differential structural requirements for fibrinogen binding to platelets and to endothelial cellsJ. Cell Biol.108(6)2519-2527(1989) 3.Ferris, D.M., Moodie, G.D., Dimond, P.M., et al.RGD-coated titanium implants stimulate increased bone formation in vivoBiomaterials20(23-24)2323-2331(1999) 4.Kunath, K., Merdan, T., Hegener, O., et al.Integrin targeting using RGD-PEI conjugates for in vitro gene transferJ. Gene Med.5(7)588-599(2003) | |||
T82150 | |||
Hyaluronan-IN-1是一种具有生物活性的12个氨基酸构成的肽类透明质酸(HA)抑制剂,HA为广泛存在于细胞外基质及细胞表面的高分子糖胺聚糖。该肽特异性地与可溶性、固定化及细胞相关的HA形态结合,能几乎完全抑制白细胞与HA底物的粘附。 | |||
T82877 | |||
Biotin-myelin basic protein (94-102) 是一种多肽片段,承担着在神经系统中促进髓鞘形成的关键角色。作为细胞膜肌动蛋白结合蛋白,髓鞘碱性蛋白(Myelin basic protein)对于维持神经纤维多层髓鞘的紧密附着至关重要,并有可能参与传递细胞外信号,以促进少突胶质细胞的细胞骨架与髓鞘的联结。 | |||
T37787 | |||
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxisome proliferator-activated receptor γ (PPARγ; Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake. Nitrolinoleates can also be metabolized by smooth muscle cells to produce nitrite derivatives which in turn form NO, leading to increased cGMP production and smooth muscle relaxation. Through the same mechanism, nitrolinoleate-derived NO suppresses leukocyte adhesion, in part through nitrosation of CD40. Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions. | |||
T36117 | |||
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.[1] It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.[2] 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.[1] | |||
T38090 | |||
3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits. In mice lacking ASA, levels of 3'-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits. 3'-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3'-sulfo galactosylsphingosine by LC-MS. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-03722 | EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is XP_005576740.1.
|
|||||
TMPY-05017 | ICAM-1/CD54 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is Q5NKV6.
|
|||||
TMPY-05050 | CEACAM5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.5 kDa and the accession number is XP_005589491.1.
|
|||||
TMPY-01578 | CD166/ALCAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD166/ALCAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is Q13740-1.
|
|||||
TMPY-01830 | VCAM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.8 kDa and the accession number is Q3UPN1.
|
|||||
TMPY-00480 | NCAM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
|
|||||
TMPY-00981 | ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) | Human | HEK293 Cells | ||
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.2 kDa and the accession number is A0A384MEK5.
|
|||||
TMPY-01647 | CEACAM5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A0A024R0K5.
|
|||||
TMPY-01142 | ICAM-1/CD54 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-1/CD54 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51 kDa and the accession number is A0A384MEK5.
|
|||||
TMPY-01349 | ICAM-1/CD54 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
|
|||||
TMPY-00947 | VCAM-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
|
|||||
TMPY-05850 | CEACAM6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1.
|
|||||
TMPY-00970 | CD31/PECAM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD31/PECAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is EAW94208.1.
|
|||||
TMPY-00971 | CEACAM6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
|
|||||
TMPY-04123 | CEACAM1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
|
|||||
TMPY-01850 | CEACAM3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.
|
|||||
TMPY-01298 | CADM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CADM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9BY67-1.
|
|||||
TMPY-01431 | L1CAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1.
|
|||||
TMPY-02745 | ESAM Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
ESAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is Q6AYD4.
|
|||||
TMPY-03039 | JAM-B Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
JAM-B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.3 kDa and the accession number is Q3MHC0.
|
|||||
TMPY-02744 | CADM3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CADM3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q1WIM3.
|
|||||
TMPY-00534 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant | Cynomolgus,Rhesus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is G7PM59.
|
|||||
TMPY-03003 | EpCAM/TROP1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
EpCAM/TROP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.8 kDa and the accession number is O55159.
|
|||||
TMPY-05587 | EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.7 kDa and the accession number is P16422.
|
|||||
TMPY-00533 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) | Cynomolgus,Rhesus | HEK293 Cells | ||
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is G7PM59.
|
|||||
TMPY-04039 | CADM3 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CADM3 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.5 kDa and the accession number is Q1WIM3.
|
|||||
TMPY-03040 | JAM-B Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
JAM-B Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.7 kDa and the accession number is Q3MHC0.
|
|||||
TMPY-02017 | ICAM-1/CD54 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.7 kDa and the accession number is Q00238-1.
|
|||||
TMPY-00239 | ICAM-1/CD54 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
ICAM-1/CD54 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 77.6 kDa and the accession number is A6JNN2.
|
|||||
TMPY-02939 | EpCAM/TROP1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
EpCAM/TROP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.2 kDa and the accession number is O55159.
|
|||||
TMPY-03520 | CD166/ALCAM Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD166/ALCAM Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.3 kDa and the accession number is G7NZQ8.
|
|||||
TMPY-00797 | ESAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q96AP7-1.
|
|||||
TMPY-00249 | CD166/ALCAM Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
CD166/ALCAM Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.9 kDa and the accession number is F7E9U2.
|
|||||
TMPY-01300 | EpCAM/TROP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
EpCAM/TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422.
|
|||||
TMPY-02936 | CD166/ALCAM Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD166/ALCAM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.5 kDa and the accession number is O35112.
|
|||||
TMPY-03912 | CD166/ALCAM Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CD166/ALCAM Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is O35112.
|
|||||
TMPY-03874 | NCAM1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
NCAM1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 79.2 kDa and the accession number is P13596-1.
|
|||||
TMPY-00798 | ESAM Protein, Human, Recombinant | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is Q96AP7-1.
|
|||||
TMPY-01312 | ESAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ESAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is Q96AP7-1.
|
|||||
TMPY-00826 | ICAM-2/CD102 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
ICAM-2/CD102 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 50.3 kDa and the accession number is P13598.
|
|||||
TMPY-01418 | ICAM-2/CD102 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-2/CD102 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P13598.
|
|||||
TMPY-04155 | NCAM2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NCAM2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is O15394-1.
|
|||||
TMPJ-00930 | VCAM-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction.
|
|||||
TMPY-00251 | ICAM-5 Protein, Human, Recombinant (aa 1-570,hFc) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (aa 1-570,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.9 kDa and the accession number is Q9UMF0.
|
|||||
TMPY-04151 | NCAM2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NCAM2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is O15394-1.
|
|||||
TMPY-06535 | CEACAM5 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
CEACAM5 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.76 kDa and the accession number is XP_005589491.1.
|
|||||
TMPY-02734 | ESAM Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ESAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is Q925F2.
|
|||||
TMPY-00388 | ICAM-5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q9UMF0.
|
|||||
TMPY-00191 | ICAM-5 Protein, Human, Recombinant (aa 1-132,hFc) | Human | HEK293 Cells | ||
ICAM-5 Protein, Human, Recombinant (aa 1-132,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.6 kDa and the accession number is Q9UMF0.
|
|||||
TMPY-02999 | BCAM Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
BCAM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q9ESS6.
|