目录号 | 产品详情 | 靶点 | |
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T73582 | MNK | ||
EB1 是一种具有有效性和选择性的 MNK 激酶抑制剂,对 MNK1和 MNK2 具有抑制作用 IC50 分别为 0.69 μM 和 9.4 μM。EB1 抑制癌细胞的生长,促进细胞凋亡,抑制 eIF4E 磷酸化。 | |||
T23706 | |||
Alminoprofen is a nonsteroidal anti-inflammatory agent. It was found to significantly suppress passive anaphylactic bronchoconstrictions at 30 mg/kg given intraduodenally. | |||
T10758 | Others | ||
Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter). | |||
T19559 | Others | ||
Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM). | |||
T63170 | |||
EB-0156 是一种有效的 ER α-葡萄糖苷酶 (α-Glu) I 和 II 的有效抑制剂,其 IC50 值分别为 0.0479 和 <0.001 μM。EB-0156 是一种 N-取代的缬草胺衍生物,具有广谱抗病毒活性。EB-0156 具有潜力进行针对现有和新兴病毒的广谱药物的研究。 | |||
T62793 | |||
EB-0150 是一种 ER α-葡萄糖苷酶 (α-Glu) I (IC50s: 0.73 μM) 和 (α-Glu) II (IC50s: 0.0337 μM) 的有效抑制剂。EB-0150 是一种 N-取代的缬草胺衍生物,具有广谱抗病毒效果。EB-0150 针对现有和新兴病毒的广谱药物具有研究潜力。 | |||
T63303 | |||
EB-0176 是 N-取代的缬草胺衍生物,表现出广谱抗病毒活性,是一种有效的 ER α-葡萄糖苷酶 (α-Glu) I 和 II 抑制剂,其 IC50s 值分别为 0.6439 和 0.0011 μM。EB-0176 表现出针对现有和新兴病毒的广谱药物的研究潜力。 | |||
T82512 | |||
EB1 peptide (Penetrating analog) 为一种Penetratin衍生的CPP(两亲性细胞穿透肽),展现了在细胞内药物输送领域的应用潜力。 | |||
T8055 | Others Autophagy | ||
TFEB activator 1 (Curcumin analog compound C1) 是转录因子 EB 的一种激活剂,有望预防或治疗阿尔茨海默病。 | |||
T8025 | Others Endogenous Metabolite | ||
Phenylglyoxylic acid (Benzoyl formate) 是一种乙苯和苯乙烯 (EB/S) 的代谢物,能够被用作人体暴露于 EB/S 的生物标志物。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03865 | EB3 Protein, Human, Recombinant (His) | Human | E. coli | ||
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role in cell migration. MAPRE3 is broadly expressed in the brain, testis, and other tissues. Diseases associated with MAPRE3 include Neuronopathy, Distal Hereditary Motor, Type Viib, and Distal Hereditary Motor Neuronopathy Type 7.
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TMPY-03496 | EBAG9 Protein, Human, Recombinant (His) | Human | E. coli | ||
RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of RCAS1 gene. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for RCAS1 gene. EBAG9 may participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
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