目录号 | 产品详情 | 靶点 | |
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T8666 | 5-HT Receptor | ||
Naratriptan 是一种5-HT1受体选择性激动剂,可作用于偏头疼。 | |||
T5336 | Potassium Channel 5-HT Receptor | ||
Zacopride hydrochloride 是5-HT3受体拮抗剂 (Ki:0.38 nM),也是5-HT4受体激动剂 (Ki:373 nM),具有抗焦虑作用。它对精神分裂症具有潜在的研究价值。 | |||
T8441 | 5-HT Receptor | ||
Lerisetron 是5-HT3拮抗剂,与 5-HT3受体具有高亲和力(pKi:9.2)。它对尿烷麻醉大鼠的 5-HT 引发的反射性心率过缓具有抑制作用。 | |||
T2815 | 5-HT Receptor | ||
Puerarin (Kakonein) 是从葛根中提取的一种异黄酮,是一种5-HT2C 受体拮抗剂。 | |||
T0525 | 5-HT Receptor Transferase | ||
Flopropione (Phloropropiophenone) 是一种解痉剂,用作 5-HT1A 受体拮抗剂,也是儿茶酚-O-甲基转移酶抑制剂。 | |||
T10162 | 5-HT Receptor | ||
5-HT3 antagonist 3 是一种高亲和力的 5-HT3 受体拮抗剂。5-HT3 antagonist 3 结合到大鼠脑皮质膜中的 5-HT3 受体,Ki 为 0.25 nM。 | |||
T2599 | 5-HT Receptor | ||
Pirenperone 是5-HT2血清素受体拮抗剂,具有一定抗焦虑作用。 | |||
T9113 | IL Receptor Anti-infection BCL P450 PARP 5-HT Receptor Caspase GABA Receptor NO Synthase | ||
Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用,还具有抗炎作用,其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡,其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。 | |||
T21629 | Dopamine Receptor 5-HT Receptor | ||
Loxapine 是 D2DR 和 D4DR 抑制剂和5-羟色胺能受体拮抗剂,是一种抗精神病药物,主要用于治疗精神分裂症。 | |||
T16669 | 5-HT Receptor | ||
PRX-08066是5-HT 受体2B 拮抗剂,IC50为3.4 nM,可诱导肺动脉的选择性血管舒张。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 | ||
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.
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TMPY-05387 | SLAMF7 Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
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TMPY-04318 | GRIK2 Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 has a role in the maintenance of urothelial CSCs/CICs and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas.
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TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death Associated Protein 6.
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TMPY-05547 | SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 | ||
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
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TMPY-05498 | SR-BI/SCARB1 Protein, Human, Recombinant (hFc) | Human | HEK293 | ||
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
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TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
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TMPK-01363 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 | ||
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.
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