目录号 | 产品详情 | 靶点 | |
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T70932 | |||
L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fibrosis markers such as TGF-β and collagen IV. | |||
TN1310 | Others | ||
6-Hydroxykaempferol 3,6-di-O-glucoside and 6-hydroxykaempferol 3,6,7-tri-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- induced platelet aggregation. | |||
T60557 | |||
TRAP-6-IN-1 (Compound 8) 是胶原蛋白和TRAP-6的双重抑制剂,IC50值分别为 17.12 μM 和 11.88 μM。TRAP-6-IN-1 非竞争性抑制激动剂诱导的血小板聚集。 | |||
T81005 | |||
Tetrapeptide-4,一种护肤产品中常用的肽,具备减少皱纹与增强胶原蛋白、弹性蛋白及纤连蛋白的功能,展现出显著的抗衰老特性。 | |||
TP2186L1 | Others | ||
PalMitoyl Tripeptide-1 hydrochloride (PalMitoyl Tripeptide-1 hydrochloride (147732-56-7 Free base)) 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响,可用于制备抗衰老化妆品。 | |||
T12585L | Others | ||
PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3(LOXL2/LOXL3)的双抑制剂,对几乎所有哺乳动物物种 LOXL2的 IC50均< 40 nM,对人类 LOXL3 的 IC50为63 nM。PXS-5153A monohydrochloride 可减少交联并改善纤维化。 | |||
TP1974 | |||
Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum | |||
T2O2683 | Endogenous Metabolite | ||
L-Proline (proline) 是人体非必需氨基酸。它是胶原蛋白的重要组成部分,对关节和肌腱的正常运作很重要。它还有助于维持和加强心脏肌肉。 | |||
T82780 | |||
Caprooyl-tetrapeptide-3 acetate 旨在减少细纹与皱纹。该化合物能够在皮质激素诱导的皮肤老化模型中刺激VII型胶原蛋白及层粘连蛋白5的表达。 | |||
T19390 | Others | ||
L-ascorbic acid 2-phosphate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01132 | COL6A3 Protein, Human, Recombinant | Human | HEK293 Cells | ||
COL6A3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 8.5 kDa and the accession number is D9ZGF2.
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TMPY-01395 | CTHRC1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
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TMPY-01860 | Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His) | Human | HEK293 Cells | ||
COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Type II collagen is specific for cartilaginous tissues. Thus COL2A1 is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. The regulation of COL2A1, likely results from a balance of both positive and negative proteins. The inhibition of COL2A1 transcription following treatment of chick sternal chondrocytes with growth factors was accompanied by increased EF1 expression. Overexpression of EF1 in differentiated chondrocytes resulted in decreased expression of a reporter construct containing a collagen II promoter/enhancer insert.
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TMPY-02848 | Adiponectin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Adiponectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q15848.
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TMPY-05556 | Adiponectin Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Adiponectin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A8K660.
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TMPJ-00948 | Endostatin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96% aa sequence identity with rat and 85‑87% with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down‑regulate angiogenesis by blocking VEGF‑induced endothelial cell migration. Endostatin may also be involved with down‑regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.
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TMPJ-00921 | COL8A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 may have a role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
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TMPY-04164 | COL6A3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
COL6A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.4 kDa and the accession number is P12111-1.
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TMPH-01113 | COL8A1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
COL8A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPJ-00804 | COL3A1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Collagen alpha-1(III) chain(Col3a1) is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a molecule of type III procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell to remove extra protein segments from their ends. Once these molecules are processed, the collagen molecules arrange themselves into long, thin fibrils. Within these fibrils, the individual collagen molecules are cross-linked to one another. These cross-links result in the formation of very strong mature type III collagen fibrils, which are found in the spaces around cells.
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TMPY-03809 | COL5A2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
COL5A2 is a component of type V collagen. It is known as the pro-alpha2(V) chain. COL5A2, together with two pro-alpha1(V) chains can form type V procollagen. These triple-stranded, rope-like procollagen molecules arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers. Type V collagen can be detected in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen.
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TMPJ-01281 | COL21A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Collagen α-1(XXI) Chain (COL21A1) is a member of the fibril-associated collagens with interrupted
helices (FACIT) family. COL21A1 is a secreted protein and contains six collagen-like domains, one
TSP N-terminal (TSPN) domain, and one VWFA domain. COL21A1 is widely expressed in many
tissues with the highest expression observed at the fetal stage. COL21A1 is stimulated by
PDGF/platelet-derived growth factor. Type XXI collagen is localized to tissues containing type I
collagen; it may serve to maintain the integrity of the extracellular matrix.
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TMPY-04288 | CTHRC1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CTHRC1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is NP_001258229.1.
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TMPY-06826 | CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 26.33 kDa and the accession number is NP_612464.1.
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TMPY-03272 | COL4A3 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a head-to-head conformation and each gene pair shares a common promoter.
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TMPY-06775 | CTHRC1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
CTHRC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.8 kDa and the accession number is NP_612464.1.
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TMPY-03960 | COL9A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
COL9A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is P20849-3.
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TMPY-04015 | COL9A1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
COL9A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 59.2 kDa and the accession number is P20849-3.
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TMPY-06795 | CTHRC1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CTHRC1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.53 kDa and the accession number is Q9D1D6.
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TMPY-02596 | GLT25D2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Glycosyl transferase 25 domain 2 (GLT25D2) is a glucosyltransferase enzyme expressed only at low levels in the nervous system. Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar (also known as the "glycosyl donor") to a glycosyl acceptor molecule, usually an alcohol. Glycosyl transferases transfer glycosyl groups onto their substrate. Localization partially defines their function. Glt25D2 enzyme showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL which contains a collagen domain.
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TMPH-01119 | COL6A2 Protein, Human, Recombinant (GST & His & Myc) | Human | E. coli | ||
Collagen VI acts as a cell-binding protein. COL6A2 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 35.2 kDa and the accession number is P12110.
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TMPH-01117 | COL18A1 Protein, Human, Recombinant (GST) | Human | E. coli | ||
COL18A1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 46.3 kDa and the accession number is P39060.
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TMPH-01112 | COL4A1 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. COL4A1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 39.9 kDa and the accession number is P02462.
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TMPH-01122 | COL6A6 Protein, Human, Recombinant (His) | Human | E. coli | ||
COL6A6 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-01111 | COL4A1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
COL4A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-01120 | COL4A2 Protein, Human, Recombinant (His) | Human | E. coli | ||
COL4A2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.3 kDa and the accession number is P08572.
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TMPH-01118 | COL18A1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
COL18A1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P39060.
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TMPH-02593 | CTHRC1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
May act as a negative regulator of collagen matrix deposition.
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TMPH-01114 | COL12A1 Protein, Human, Recombinant (His) | Human | E. coli | ||
COL12A1 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-02590 | COL4A2 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
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TMPH-01115 | COL15A1 Protein, Human, Recombinant (His) | Human | E. coli | ||
COL15A1 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-01121 | COL4A3 Protein, Human, Recombinant (His) | Human | E. coli | ||
COL4A3 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-02588 | COL12A1 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
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TMPH-02592 | CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His) | Mouse | HEK293 Cells | ||
May act as a negative regulator of collagen matrix deposition.
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TMPH-02591 | COL4A3 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
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TMPH-01123 | CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) | Human | HEK293 Cells | ||
May act as a negative regulator of collagen matrix deposition. CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 52 kDa and the accession number is Q96CG8.
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TMPY-03266 | COL4A3BP Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. One isoform of COL4A3BP is also involved in ceramide intracellular transport. COL4A3BP specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. An autoimmune response directed at this antigen can cause goodpasture disease.
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TMPH-02589 | COL26A1 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells | ||
N/A. COL26A1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is Q91VF6.
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TMPY-01681 | Adiponectin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Adiponectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is Q60994.
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TMPJ-00605 | GPVI Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like domains initiates signaling through the FcR gamma ITAM sequence. Dimerization of GPVI (2:2 with FcR gamma ) and N-glycosylation greatly enhances collagen binding. Type I and III collagens are strong thrombus-forming components in the vascular subendothelium and atherosclerotic plaques. GPVI initiates binding to fibrillar collagens under flow conditions, then activates integrin alpha 2 beta 1 which binds collagen more tightly. GPVI deficiencies cause only a mild bleeding tendency, probably because integrin alpha 2 beta 1 is able to minimally initiate collagen binding. Normal human GPVI concentration can vary widely and affect maximum thrombin generation. Engagement of GPVI by collagens or other agonists, including autoantibodies, causes calmodulin-regulated metalloproteinase cleavage of the 57 kDa ECD and depletes surface GPVI.
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TMPH-01116 | COL17A1 Protein, Human, Recombinant (His) | Human | E. coli | ||
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. COL17A1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.4 kDa and the accession number is Q9UMD9.
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TMPJ-00292 | CD36 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1,oxidized lowdensity lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, β amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparuminfected erythrocytes. CD36 is required for the antiangiogenic effects of thrombospondin-1 in the corneal neovascularization assay. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues.
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TMPH-00350 | Adiponectin Protein, Feline, Recombinant | Feline | E. coli | ||
Adiponectin Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24.9 kDa and the accession number is A4PB30.
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TMPH-00219 | Adiponectin Protein, Bovine, Recombinant (His) | Bovine | P. pastoris (Yeast) | ||
Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is Q3Y5Z3.
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TMPJ-00995 | Serpin H1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. Serpin H1 may be a marker for cancer and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes.
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TMPH-00419 | Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc) | C.perfringens | E. coli | ||
Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization. Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen. Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.7 kDa and the accession number is P43153.
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TMPH-02342 | Collagenase Protein, Hypoderma lineatum, Recombinant (His & Myc) | Hypoderma lineatum | E. coli | ||
This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.
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TMPY-01009 | TGFBI Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.
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TMPJ-01172 | IL-17 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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TMPH-00010 | MMP-14 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
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