目录号 | 产品详情 | 靶点 | |
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T35812 | |||
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This compound increases fluorescence by 233% in a SIRT1 activity assay. [Activator activity was defined as the percentage of signal increase relative to signal window in the following formula: 100 x (Sample - Signallow)/(Signalhigh - Signallow)]. CAY10591 suppresses TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 pg/ml (control) to 104 and 53 pg/ml with 20 and 60 µM CAY10591, respectively. This activator also has a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which would indicate the potential of SIRT1 activators for anti-obesity or anti-diabetic purposes. | |||
T35456 | |||
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. It is used, both in vitro and in vivo, to promote the correct folding of proteins that require disulfide bonds for functionality. For in vitro applications, BMC may be used to facilitate protein refolding of solubilized proteins from inclusion bodies. Reducing agents, like dithiothreitol, may interfere with refolding. BMC may also be added to the growth medium of cells, including yeast cells, to enhance the folding of proteins with disulfide bonds in vivo. | |||
T79149 | Others | ||
Magmas-IN-1(compound 9)为针对Magmas的小分子抑制剂(SMMI),后者是线粒体相关粒细胞-巨噬细胞集落刺激因子(GM-CSF)的信号分子,并参与骨髓细胞的GM-CSF诱导基因表达。Magmas-IN-1作用于Magmas,进而调控线粒体功能,并在4 μM浓度下可显著抑制酵母细胞的增殖。 | |||
T34917 | |||
Traxanox sodium 是一种可口服的利尿剂。Traxanox sodium 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox sodium 对抑制BALB/c小鼠抗体产生的恢复作用。 | |||
T22239 | |||
AMI-1 free acid 是一种有效的,具有细胞渗透性和可逆的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂,对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 μM 和 3.0 μM。AMI-1 free acid 通过阻断肽-底物结合发挥 PRMTs 抑制作用。 | |||
T82451 | |||
Epsilon-polylysine 是由特定细菌产生的抗菌肽,主要用作食品和饮料的防腐剂。它能有效抑制各类微生物如细菌、酵母菌和霉菌的生长。该化合物因其热稳定性、耐酸性和广谱抗菌活性,成为理想的食品添加剂。 | |||
T35423 | |||
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM. | |||
T75576 | |||
Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡,并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。 | |||
T81127 | |||
Sophorose 是一种由酵母产生的微生物糖脂(sophorolipid)的二糖组分,该酵母以槐糖脂(sophorolipids)而著名。作为一种生物表面活性剂,槐糖脂的疏水性使其在多个领域中有着应用价值,例如,它具有抗菌、抗真菌、杀精子、杀病毒和抗癌的功能性特性。此外,在木霉(Trichoderma reesei)发酵过程中,研究已证实Sophorose是促进纤维素酶(cellulase genes)表达的有效诱导剂。 | |||
T75509 | |||
Pulcherriminic acid 是环状二肽抗菌剂,对Fe3+有高亲和力,主要在芽孢杆菌和酵母中发现。该化合物通过非酶促反应与铁离子螯合,生成细胞外红色素pulcherrimin,通过竞争铁营养达到抗菌效果。Pulcherriminic acid 在食品、农业和医疗等领域具有广泛应用潜力。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-06984 | EGF Protein, Mouse, Recombinant (Yeast) | Mouse | P. pastoris (Yeast) | ||
EGF Protein, Mouse, Recombinant (Yeast) is expressed in yeast. The predicted molecular weight is 6 KDa. and the accession number is P01132.
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TMPH-00945 | APOB Protein, Human, Recombinant (Yeast, His) | Human | P. pastoris (Yeast) | ||
APOB Protein, Human, Recombinant (Yeast, His) is expressed in Yeast.
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TMPY-00358 | Arp3/ACTR3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Arp3/ACTR3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.1 kDa and the accession number is A0A024RAI1.
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TMPH-01020 | BTN3A1 Protein, Human, Recombinant (Yeast, His) | Human | P. pastoris (Yeast) | ||
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the accession number is O00481.
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TMPY-01948 | COQ7 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which belongs to theCOQ7 family. It is expressed dominantly in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. This enzyme is responsible for the hydroxylation of 5-demethoxyubiquinone to 5-hydroxyubiquinone. Human COQ7 protein is mostly helical, and contains an alpha-helical membrane insertion. It has a potential N-glycosylation site, a phosphorylation site for protein kinase C and another for casein kinase II, and three N-myristoylation sites. COQ7 is involved in lifespan determination in ubiquinone-independent manner. It is also involved in ubiquinone biosynthesis. COQ7 is potential central metabolic regulator.
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TMPY-02238 | MAD2L1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 family. MAD2L1 is a component of the spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase-promoting complex by sequestering CDC2 until all chromosomes are aligned at the metaphase plate. MAD2L1 has two highly different native conformations, an inactive open conformation that cannot bind CDC2 and that predominates in cytosolic monomers, and an active closed conformation. MAD2L1 in the closed conformation preferentially dimerizes with another molecule in the open conformation, but can also form a dimer with a molecule in the closed conformation. Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and MAD2L1 in the closed conformation promotes binding of another molecule of MAD2L1 in the open conformation and the conversion of the open to the closed-form and thereby promotes interaction with CDC2.
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TMPH-01337 | FGFR1 Protein, Human, Recombinant (Yeast, His) | Human | P. pastoris (Yeast) | ||
FGFR1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.4 kDa and the accession number is P11362.
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TMPH-02291 | ISG15 Protein, Human, Recombinant (Yeast, His) | Human | P. pastoris (Yeast) | ||
ISG15 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.5 kDa and the accession number is P05161.
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TMPH-02416 | Albumin Protein, Macaca fascicularis, Recombinant (Yeast, His) | Cynomolgus | P. pastoris (Yeast) | ||
Albumin Protein, Macaca fascicularis, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 68.0 kDa and the accession number is A2V9Z4.
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TMPH-00747 | FimH Protein, E. coli, Recombinant (Yeast, His) | E. coli | P. pastoris (Yeast) | ||
Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
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TMPH-03480 | PrgJ Protein, Salmonella typhimurium, Recombinant (Yeast, His & Myc) | Salmonella typhimurium | P. pastoris (Yeast) | ||
Required for invasion of epithelial cells. PrgJ Protein, Salmonella typhimurium, Recombinant (Yeast, His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is P41785.
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TMPH-00593 | DnaK Protein, E. coli, Recombinant (Yeast, His) | E. coli | P. pastoris (Yeast) | ||
Acts as a chaperone.
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TMPH-02433 | LY6G6D Protein, Cynomolgus, Recombinant (Yeast, His) | Cynomolgus | P. pastoris (Yeast) | ||
LY6G6D Protein, Cynomolgus, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.1 kDa and the accession number is UJY53414.1.
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TMPH-00013 | Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His) | Abrus precatorius | P. pastoris (Yeast) | ||
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 30.1 kDa and the accession number is P11140.
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TMPH-00116 | UGT89C1 Protein, Arabidopsis thaliana, Recombinant (Yeast, His) | Arabidopsis thaliana | P. pastoris (Yeast) | ||
UGT89C1 Protein, Arabidopsis thaliana, Recombinant (Yeast, His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9LNE6.
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THMH-00001 | CD133/PROM1 Recombinant,Human(Yeast expression,His) | ||||
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TMPH-00046 | Aln g I Protein, Alnus glutinosa, Recombinant (Yeast, His) | European alder | P. pastoris (Yeast) | ||
Aln g I Protein, Alnus glutinosa, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 19.2 kDa and the accession number is P38948.
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TMPH-00262 | Bovine coronavirus (strain OK-0514) Spike glycoprotein (Yeast, His) | BCoV | P. pastoris (Yeast) | ||
Bovine coronavirus (strain OK-0514) Spike glycoprotein (Yeast, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 36.5 kDa and the accession number is Q9QAQ8.
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TMPY-00499 | TMP21 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptional reporter activity. In a xenograft cancer model, where previously TGF-beta was shown to elicit tumor-promoting effects, gain-of-function and loss-of-function studies for TMED10 revealed a decrease and increase in the tumor size, respectively. That TMED10 expression levels are the key determinant for efficiency of TGF-beta receptor complex formation and signaling.
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TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | P. pastoris (Yeast) | ||
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
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TMPH-00804 | HBV-C subtype ayw (isolate China/Tibet127/2002) Capsid protein (Yeast, His) | HBV-C | P. pastoris (Yeast) | ||
HBV-C subtype ayw (isolate China/Tibet127/2002) Capsid protein (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P0C6H7.
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TMPH-00004 | RAC1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
RAC1 Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 24.6 kDa; 30 kDa, reducing conditions and the accession number is P63000.
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TMPY-05462 | Albumin Protein, Human, Recombinant, Biotinylated | Human | P. pastoris (Yeast) | ||
Albumin Protein, Human, Recombinant, Biotinylated is expressed in yeast. The predicted molecular weight is 66.5 kDa and the accession number is P02768-1.
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TMPY-04878 | IGF1/IGF-I Protein, Mouse, Recombinant | Mouse | P. pastoris (Yeast) | ||
IGF1/IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.
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TMPY-00118 | MCP-1/CCL2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
MCP-1/CCL2 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 10.1 kDa and the accession number is P13500.
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TMPY-00265 | Interferon alpha 2/IFNA2 Protein, Human, Recombinant | Human | P. pastoris (Yeast) | ||
Interferon alpha 2/IFNA2 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 19.3 kDa and the accession number is P01563.1.
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TMPY-04578 | Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 20.8 kDa and the accession number is L0N195.
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TMPY-03782 | Albumin Protein, Human, Recombinant | Human | P. pastoris (Yeast) | ||
Albumin Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 66.4 kDa and the accession number is P02768-1.
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TMPY-00007 | Interferon alpha 2/IFNA2 Protein, Mouse, Recombinant | Mouse | P. pastoris (Yeast) | ||
Interferon alpha 2/IFNA2 Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 19.4 kDa and the accession number is B1AYH7.
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TMPH-00002 | PSMD3 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
PSMD3 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63 kDa; 70 kDa, reducing conditions and the accession number is O43242.
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TMPY-00649 | MIP-1 alpha/CCL3 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
MIP-1 alpha/CCL3 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is A0N0R1.
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TMPY-04726 | IL-8/CXCL8 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
IL-8/CXCL8 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.8 kDa and the accession number is A0A024RDA5.
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TMPH-00699 | BamA Protein, E. coli, Recombinant (His) | E. coli | P. pastoris (Yeast) | ||
BamA Protein, E. coli, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30 kDa and the accession number is P0A940.
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TMPY-04239 | IL-28A Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
IL-28A Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8IZJ0.
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TMPY-04727 | GDF-15 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
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TMPY-04976 | PDGFC Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
PDGFC Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.4 kDa and the accession number is Q8CI19.
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TMPH-00003 | LASP1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
LASP1 Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 31.2 kDa; 43 kDa, reducing conditions and the accession number is Q14847.
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TMPH-00005 | YAP1 Protein, Human, Recombinant (Isoform 9, His) | Human | P. pastoris (Yeast) | ||
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
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TMPH-03617 | Miraculin Protein, Synsepalum dulcificum, Recombinant (His) | Synsepalum dulcificum | P. pastoris (Yeast) | ||
Miraculin has the property of modifying a sour taste into a sweet taste. This alteration of taste perception persists for many minutes. Miraculin Protein, Synsepalum dulcificum, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 23.4 kDa and the accession number is P13087.
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TMPY-04644 | PDGFB Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P01127-2.
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TMPY-03956 | Fas Ligand Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
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TMPH-02066 | SLURP2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
SLURP2 Protein, Human, Recombinant (His) is expressed in Yeast.
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TMPH-00442 | PGK1 Protein, Cricetulus griseus, Recombinant (His) | Chinese hamster | P. pastoris (Yeast) | ||
PGK1 Protein, Cricetulus griseus, Recombinant (His) is expressed in Yeast.
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TMPH-00450 | SVSP Protein, Crotalus atrox, Recombinant (His) | Crotalus atrox | P. pastoris (Yeast) | ||
SVSP Protein, Crotalus atrox, Recombinant (His) is expressed in Yeast.
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TMPH-02664 | Aldolase C Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Aldolase C Protein, Mouse, Recombinant (His) is expressed in Yeast.
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TMPH-02756 | LECT2 Protein, Mouse, Recombinant (His & Myc) | Mouse | P. pastoris (Yeast) | ||
LECT2 Protein, Mouse, Recombinant (His & Myc) is expressed in Yeast.
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TMPH-02746 | Kallikrein 8 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Kallikrein 8 Protein, Mouse, Recombinant (His) is expressed in Yeast.
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TMPY-06693 | Cor a 14 Protein, Corylus avellana, Recombinant | Corylus avellana | P. pastoris (Yeast) | ||
Cor a 14 Protein, Corylus avellana, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 10.5 kDa.
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TMPY-06667 | Ara h 9.0101 Protein, Arachis hypogaea, Recombinant | Arachis hypogaea | P. pastoris (Yeast) | ||
Ara h 9.0101 Protein, Arachis hypogaea, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 18.9 kDa.
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TMPH-00488 | Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) | Canine | P. pastoris (Yeast) | ||
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) is expressed in Yeast.
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