目录号 | 产品详情 | 靶点 | |
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T79177 | Xanthine Oxidase | ||
URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂,对xanthine oxidase展现出优异的抑制效果,IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取,其Ki值达到0.145 μM。在动物模型中,URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平,并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。 | |||
T73966 | |||
Febuxostat sec-butoxy acid 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂,Ki 为 0.6 nM。 | |||
T82649 | |||
Cyanidin,作为一种抗氧化剂,能够保护 DNA 免受裂解,有效清除自由基,并显著抑制 XO 活性。 | |||
T61060 | |||
Febuxostat (TEI 6720) sodium 在痛风和高尿酸血症研究中具有潜力,它是一种有效的、选择性的、非嘌呤的黄嘌呤氧化酶 (XO)抑制剂,Ki 值为 0.6 nM。 | |||
T35976 | |||
Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in hetero-substrate" inhibition at nanomolar concentrations. However | |||
TP1886 | |||
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary | |||
T79331 | Xanthine Oxidase | ||
Antioxidant agent-13(Compound 5f)为一种效能显著的抗氧化剂,其抑制DPPH和FRAP的IC50值分别为80.33 μM和85.69 μM;同时,Antioxidant agent-13对LOX和XO酶的抑制作用亦强,对应IC50值为16.85 μM及23.01 μM。 | |||
T79175 | Xanthine Oxidase | ||
URAT1&XO inhibitor 1(化合物29)是一种对URAT1(IC50≈10μM)和黄嘌呤氧化酶(IC50=1.01μM)具有双重抑制作用的抑制剂。该化合物能够在氧酸钾引起的高尿酸血症大鼠模型中降低血尿酸水平,已广泛应用于高尿酸血症的研究。 | |||
T75501 | |||
Morin 3-O-β-D-glucopyranoside 是一种天然类黄酮,具有抗真菌、抗癌和抗氧化活性。Morin 3-O-β-D-glucopyranoside 抑制逆转录酶、蛋白酪氨酸激酶和黄嘌呤氧化酶,还具有抗 HIV、抗动脉硬化和超氧化物清除活性。 | |||
T62350 | |||
XO/COX/LOX-IN-1 是一种黄嘌呤氧化酶/环氧酶/脂氧合酶 XO/COX/LOX 的有效抑制剂。XO/COX/LOX-IN-1 能够用于研究炎症、癌症以及代谢性疾病。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02464 | Catalase/CAT Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin heme groups that allow the enzyme to react with the hydrogen peroxide. The optimum PH of human catalase is approximately 7 and the optimum temperature is at 37 degree. Both the PH optimum and temperature for other catalases varies depending on the species. Catalase can be inhibited by a flux of O2-generated in situ by the aerobic xanthine oxidase reaction. This inhibition of catalase by O2-provides the basis for a synergism between superoxide dismutase and catalase.Such synergisms have been observed in vitro and may be significant in vivo. Catalase is used in the food industry for removing hydrogen peroxide from milk prior to cheese production. Another use is in food wrappers where it prevents food from oxidizing. Catalase is also used in the textile industry, removing hydrogen peroxide from fabrics to make sure the material is peroxide-free.
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TMPJ-00764 | Catalase/CAT Protein, Human, Recombinant | Human | E. coli | ||
Catalase (CAT) is a member of the catalase family. It exists as a homotetramer that occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase is localized in the peroxisome. Catalase promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells, and normal and transformed fibroblast cells. Defects in CAT are the cause of acatalasemia which is characterized by absence of catalase activity in red cells and is associated with ulcerating oral lesions.
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