目录号 | 产品详情 | 靶点 | |
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T37574 | |||
N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage. | |||
T74245 | |||
DSPE-PEG为磷脂-聚合物偶联物,在药物递送应用中有重要用途。该材料能作为纳米载体的基础,用以增强血液循环时间、稳定性及封装效率。 | |||
T76135 | |||
Hemicellulase(半纤维素酶),糖苷水解酶家族成员,广泛应用于生化研究领域。该酶能够分解植物纤维中的葡萄糖及其与水分子的聚合物,是自然界植物生物量及碳流降解的关键酶类。 | |||
T11849 | Others | ||
Lignin (Lignine) 是一种具有生物可降解性和生物相容性的天然复合生物聚合物。它是植物细胞壁的主要成分,是一种可再生的芳香族聚合物,具有显著的抗氧化作用。 | |||
T37850 | |||
Chitobiose is a dimer of β-1,4 linked glucosamine units derived from chitin, which, in turn, is a long chain polymer of N-acetylglucosamine that is a primary component of fungal cell walls and arthropod exoskeletons. Chitobiose octaacetate is a form of chitobiose containing eight acetate groups. It is formed by the acetolysis of chitin. Chitobiose octaacetate can be used for the synthesis of chitobiose oxazoline and other chitin precursors. | |||
T19902 | |||
C.I. 15670是一种颜料,为红紫色粉末。可用于油墨、染料激光器、乙烯基聚合物制造、纺织品铁、钙、铝、钽的测定、工业水中硬度的监测、饮用水中二氧化氯的测量、降血糖剂、核荧光染料等。 | |||
T20612 | |||
4,5,6,7-Tetrachlorophthalide is a fungicide used for the control of rice blast. It has a role as a melanin synthesis inhibitor and an antifungal agrochemical. | |||
T77275 | |||
DSPE-PEG-SH (MW 2000)是由PEG 修饰的磷脂与马来酰亚胺反应形成的聚合物。该两性聚合物可在水溶液中形成脂质双分子层,可用于包埋活性分子,用于药物递送系统,如mRNA 疫苗。 | |||
T82873 | |||
Biotin-PEG-Alk (MW 10000)为生物素标记的PEG衍生物,是一种点击化学试剂。其中,生物素作为酶辅因子,应用于蛋白质标记;PEG为低毒性的亲水聚合物;而Alk作为无环脂肪烃,具有提高生物素与靶点结合效率的功能。Biotin-PEG-Alk的Alkyne基团可通过CuAAc与含Azide基团的分子发生反应。 | |||
T38296 | |||
Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 μM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacterial activity against a panel of 8 mollicutes (MICs = 1.56-12.5 μM). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-06071 | SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) | SARS-CoV-2 | Baculovirus Insect Cells | ||
SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 108.3 kDa and the accession number is YP_009725307.1.
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TMPH-00360 | DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant | Cenarchaeum symbiosum | E. coli | ||
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.0 kDa and the accession number is A0RYM0.
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TMPH-03230 | PHB depolymerase Protein, Ralstonia pickettii, Recombinant (His) | Ralstonia pickettii | E. coli | ||
This protein degrades water-insoluble and water-soluble PHB to monomeric D(-)-3-hydroxybutyrate. PHB depolymerase Protein, Ralstonia pickettii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.9 kDa and the accession number is P12625.
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TMPH-00613 | DNA polymerase II Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
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TMPH-02357 | Influenza A H3N2 (strain A/X-31) Polymerase acidic Protein (His) | H3N2 | E. coli | ||
Influenza A H3N2 (strain A/X-31) Polymerase acidic Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession number is Q9IQ47.
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TMPH-00427 | DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant | Colwellia psychrerythraea | E. coli | ||
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 39.3 kDa and the accession number is Q487H6.
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TMPH-00533 | T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) | Escherichia phage T7 | E. coli | ||
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible to the DNA polymerase, thus facilitating the DNA opening. Plays also a role in viral DNA packaging, probably by pausing the transcription at the right end of concatemer junction to allow packaging complex recruitment and beginning of the packaging process.
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TMPH-00523 | DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) | Escherichia phage RB69 | E. coli | ||
Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose. DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is Q38087.
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TMPH-02356 | Influenza A H1N1 (strain A/USA:Huston/AA/1945) Polymerase acidic Protein (His) | H1N1 | P. pastoris (Yeast) | ||
Influenza A H1N1 (strain A/USA:Huston/AA/1945) Polymerase acidic Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is A4U6V9.
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TMPH-00426 | DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) | Colwellia psychrerythraea | E. coli | ||
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 43.3 kDa and the accession number is Q487H6.
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TMPJ-00792 | DNA PolymeraseBeta Protein, Human, Recombinant (His) | Human | E. coli | ||
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The activity cannot be affected by Aphidicolin, which is an inhibitor of DNA polymerase β.
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TMPH-01450 | Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) | HHV-6A | P. pastoris (Yeast) | ||
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) is expressed in Yeast.
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TMPY-02483 | ATP citrate lyase/ACLY Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.
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TMPH-03438 | CHS1 Protein, S. cerevisiae, Recombinant (His) | Saccharomyces cerevisiae | E. coli | ||
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation during adverse conditions. CHS1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is P08004.
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TMPH-03714 | HAS1 Protein, Xenopus tropicalis, Recombinant (His & Myc) | Xenopus tropicalis | E. coli | ||
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.
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TMPH-03569 | IcaB Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli | ||
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. IcaB Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.9 kDa and the accession number is Q7A349.
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TMPJ-01433 | Fibronectin Protein, Human, Recombinant (ED-B domain, Avi & His), Biotinylated | Human | E. coli | ||
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
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TMPJ-00486 | SUMO2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
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TMPY-01290 | CHIT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosidase activity is widely used during treatment of this pathology by enzyme replacement therapy. Its elevated plasma level reflects gradual intralysosomal accumulation in Gaucher cells (lipid-loaded macrophages). Macrophages overloaded by the enzyme accumulated in lysosomal material (lipids) were shown to secrete chitotriosidase; its increased expression was noted in several lysosomal storage diseases and atherosclerosis. In addition to lipid storage disorders, where Chit activity has longer been used as a marker of disease activity and therapeutic response, elevation of plasma Chit may occur in hematological disorders with storage of erythrocyte membrane breakdown products as thalassemia and different systemic infectious diseases sustained by fungi and other pathogens. Recently, increased Chit activity was demonstrated in CNS from patients with different neurological disorders. Chitotriosidase is believed to play a role in mechanisms of immunity and protection against chitin-containing pathogens.
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TMPY-01918 | J chain Protein, Human, Recombinant (His) | Human | E. coli | ||
Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA, it induces larger polymers. Immunoglobulin J chain / IGJ also helps to bind these immunoglobulins to the secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.
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