T15871
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m-PEG4-Boc
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m-PEG4-Boc is a cleavable 4-unit polyethylene glycol (PEG) linker, widely employed in the synthesis of antibody-drug conjugates (ADCs) [1]. Additionally, m-PEG4-Boc serves as a PEG-based PROTAC linker, enabling its utilization in the synthesis of PROTACs [2].
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T17559
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Biotin-PEG12-hydrazide
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Biotin-PEG12-hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T18854
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Tos-PEG8-Tos
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Tos-PEG8-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T16918
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SPDP-PEG6-NHS ester
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SPDP-PEG6-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T17474
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Azide-PEG9-amido-C8-Boc
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Azide-PEG9-amido-C8-Boc is a polyethylene glycol (PEG) derived linker compound utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
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T18699
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SNPB
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SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
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T17812
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DBCO-SS-amine
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DBCO-SS-amine is a cleavable linker vital in ADC synthesis. DBCO-SS-amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
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T16595
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Propargyl-PEG10-Boc
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Propargyl-PEG10-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T16216
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N-(Boc-PEG4)-NH-PEG4-NH-Boc
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N-(Boc-PEG4)-NH-PEG4-NH-Boc is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker, specifically designed for the synthesis of PROTACs [1].
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T17704
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Bromoacetamido-PEG9-ethylcarbamoyl-C8-Boc
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Bromoacetamido-PEG9-ethylcarbamoyl-C8-Boc represents a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].
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T16205
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N-Boc-N-bis(PEG2-propargyl)
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N-Boc-N-bis(PEG2-propargyl) is a PEG-derived linker employed for synthesizing PROTACs[1].
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T18285
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Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
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Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a polyethylene glycol (PEG)-based linker essential for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
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T16820
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S-Acetyl-PEG3-azide
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S-Acetyl-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T14634
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Bis-PEG3-acid
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Bis-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T14533
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Benzyl-PEG2-amine
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Benzyl-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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T17836
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DMAC-SPP
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DMAC-SPP is a cleavable linker vital in ADC synthesis. DMAC-SPP joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
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T17648
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Boc-C16-NHS ester
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Boc-C16-NHS ester, an alkyl/ether-based PROTAC linker, enables the synthesis of PROTACs[1].
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T17796
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DBCO-PEG4-Desthiobiotin
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DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
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T17732
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CL2A
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CL2A is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker, characterized by its ability to induce a bystander effect. It forms a disulfide bond with an antibody at a cysteine residue. Labetuzumab govitecan utilizes this linker for its drug conjugation[1].
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T17416
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Amino-PEG20-acid
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Amino-PEG20-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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