目录号 | 产品详情 | 靶点 | |
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T41083 | |||
pNP-ADPr is a colorimetric substrate employed in the first continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Its utilization facilitates research on poly(ADP-ribose) polymerase (PARP) enzymes. | |||
T12388 | Others | ||
PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor. | |||
T12229 | Others | ||
Niraparib metabolite M1 is niraparib metabolite, niraparib is a novel poly(ADP-Ribose) polymerase (PARP) inhibitor. | |||
T40394 | |||
Benzamide-15N (NSC-3114-15N) is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP). | |||
T13333 | Others | ||
WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221). | |||
T75344 | |||
NCT-TFP 是 PARP 探针,用于鉴定聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。 | |||
T61879 | |||
PARP1-IN-7 是一种聚 ADP 核糖聚合酶-1(PARP1)的抑制剂,作为抗癌剂。 | |||
T69185 | |||
INO-1001 methanesulfonate is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. | |||
T39365 | |||
PDD00017238 demonstrates a robust inhibitory effect on Poly(ADP-ribose) Glycohydrolase (PARG), displaying EC50 values of 40 nM in biochemical assay and 55 nM in cell POM assessment. | |||
T68736 | |||
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor that induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 114.5 kDa and the accession number is A0A024R3T8.
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TMPY-02465 | PARP Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 115 kDa and the accession number is Q921K2.
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TMPY-02421 | PARP3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory.
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TMPH-01091 | CHD1L Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. CHD1L Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.3 kDa and the accession number is Q86WJ1.
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TMPY-02831 | Caspase-7 Protein, Human, Recombinant (His) | Human | E. coli | ||
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen, heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.
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