目录号 | 产品详情 | 靶点 | |
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T63704 | |||
FGFR4-IN-11 是选择性的、有效的、共价结合的 FGFR4 抑制剂 (IC50: 2.1 nM)。FGFR4-IN-11 能够明显抑制 FGF19/FGFR4 信号通路,表现出抗癌效果。 | |||
T5001 | VEGFR FGFR PDGFR | ||
Nintedanib esylate (BIBF 1120 esylate) 是一种有效的三重血管激酶抑制剂,能够抑制 VEGFR1 (IC50:34 nM)、VEGFR2 (IC50:13 nM)、VEGFR3 (IC50:13 nM),FGFR1 (IC50:69 nM)、FGFR2 (IC50:37 nM)、FGFR3 (IC50:108 nM),PDGFRα (IC50:59 nM)、PDGFRβ (IC50:65 nM)。 | |||
T64107 | |||
FGFR3-IN-1 (compound 1) 是一种成纤维细胞生长因子受体 (FGFR) 抑制剂,可抑制FGFR1 (IC50: 40 nM),FGFR2 (IC50: 5.1 nM) 和 FGFR3 (IC50: 12 nM)。FGFR3-IN-1 能够用于研究膀胱癌。 | |||
T82405 | FGFR | ||
FGFR3-IN-6为FGFR3选择性抑制剂,具有低于350 nM 的IC50,适用于癌症研究领域。 | |||
T64015 | |||
FGFR4-IN-6 是一种共价的、可逆的 FGFR4 抑制剂 (IC50: 5.4 nM),表现出良好的口服药代动力学特性。 在 Hep3B2.1-7 HCC 细胞系的异种移植小鼠模型中,FGFR4-IN-6 能够明显诱导肿瘤消退,且无明显的毒性。 | |||
T73121 | FGFR | ||
FGFR4-IN-8 (Compound 7v) 是 ATP 竞争性、高选择性的 FGFR4 野生型及其突变体共价抑制剂,对 FGFR4、FGFR4V550L、FGFR4V550M 及 FGFR4C552S 的 IC50 值分别为 0.5、0.25、1.6、931 nM。该化合物能有效抑制 Hep3B 肝细胞癌细胞增殖,显示出显著的抑制效果,具有潜在的临床应用价值。 | |||
T73146 | |||
FGFR3-IN-5 是一种有效的选择性 FGFR3抑制剂,对 FGFR3、FGFR2 和 FGFR1的 IC50值分别为 3、44、和 289 nM。FGFR3-IN-5 可用于癌症的研究。 | |||
T63850 | |||
FGFR2-IN-3 hydrochloride 是一种选择性的、口服具有活力的 FGFR2 抑制剂。 | |||
T78830 | FGFR | ||
FGFR1 inhibitor7(compound 5),作为一种FGFR1络氨酸激酶抑制剂,具有0.33 nM的IC50。它对多种人癌细胞系显示出广谱的细胞毒性,能在2.1 μM的IC50抑制MOLT3细胞系。 | |||
T63816 | |||
FGFR1 inhibitor-6 是 FGFR1 的有效抑制剂 (IC50: 16.31 nM),具有细胞毒活性。FGFR1 inhibitor-6 能够将细胞周期阻滞在前 G1 和 G2/M 期并诱导细胞凋亡 (apoptosis) 。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03357 | FGFR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FGFR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is AAA39377.1.
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TMPY-01011 | FGFR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
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TMPY-06036 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
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TMPY-06034 | FGFR1 Protein, Human, Recombinant (beta (IIIb), His) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.
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TMPY-00974 | FGFR4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0A0R4IZY3.
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TMPY-01019 | FGFR4 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the accession number is A0A0R4IZY3.
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TMPY-03389 | FGFR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.5 kDa and the accession number is AAA39377.1.
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TMPK-00379 | FGFR4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
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TMPK-01322 | FGFR4 Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells | ||
FGFR4 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.66 kDa and the accession number is XP_028705775.1.
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TMPK-00381 | FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
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TMPK-00378 | FGFR4 beta Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR4 beta Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
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TMPK-00380 | FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
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TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession number is P11362-7.
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TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession number is P11362-7.
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TMPY-00973 | FGFR3 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
FGFR3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is Q7TSI8.
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TMPY-01208 | FGFR3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is Q7TSI8.
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TMPK-00847 | FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the accession number is P21803-2.
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TMPK-00475 | FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.2 kDa and the accession number is A0A2K5TL84-1.
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TMPJ-00388 | FGFR2IIIc Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FGFR2IIIc Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802.
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TMPK-00398 | FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) | Human | HEK293 Cells | ||
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
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TMPY-01781 | FGFR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.9 kDa and the accession number is P16092-1.
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TMPY-01782 | FGFR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FGFR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.5 kDa and the accession number is P16092-1.
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TMPK-00400 | FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.3 kDa and the accession number is P21802-3.
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TMPK-00399 | FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
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TMPY-02112 | FGFR4 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
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TMPY-05777 | FGFR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.15 kDa and the accession number is NP_001341297.1.
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TMPK-00397 | FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.2 kDa and the accession number is P21802-1.
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TMPY-06033 | FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is H9FRD4.
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TMPY-05761 | FGFR1 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
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TMPY-04371 | FGFR1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.
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TMPY-04165 | FGFR3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1.
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TMPY-06035 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) | Human | HEK293 Cells | ||
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
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TMPJ-00389 | FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 72-95 KDa and the accession number is P21802.
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TMPY-00972 | FGFR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1.
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TMPJ-00390 | FGFR2IIIb Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FGFR2IIIb Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-90 KDa and the accession number is P21802-3.
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TMPK-00388 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22607-2.
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TMPK-00385 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.1 kDa and the accession number is P22607-1.
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TMPK-00389 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.5 kDa and the accession number is P22607-2.
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TMPY-00423 | FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) | Human | HEK293 Cells | ||
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.3 kDa and the accession number is P21802-17.
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TMPK-00686 | FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the accession number is E9QNJ9.
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TMPK-00390 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22607-2.
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TMPK-00386 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607.
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TMPK-00384 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607.
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TMPY-00341 | FGFR3 Protein, Human, Recombinant (alpha IIIb, His) | Human | HEK293 Cells | ||
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
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TMPJ-00391 | FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) | Human | HEK293 Cells | ||
FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
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TMPK-00391 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.
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TMPK-00387 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts..
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TMPJ-01224 | FGFRL1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.
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TMPY-01360 | FGFRL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Fibroblast growth factor receptor-like 1 (FGFRL1) also known as Fibroblast growth factor receptor 5 (FGFR5), is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A unique feature of FGFRL1/FGFR5 is that it does not contain an intracellular tyrosine kinase domain. Some muscle types, including the muscles of the tongue and the diaphragm, express FGFRL1/FGFR5 at relatively high level. In contrast, the heart and the skeletal muscles of the limbs, as well as many other organs (brain, lung, liver, kidney, gut) express Fgfrl1 only at basal level. It is conceivable that FGFRL1/FGFR5 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-00806 | FGFR4 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is P22455-1.
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